| Radiological assessment of necrosis in glioblastoma: variability and prognostic value. | |
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MedLine Citation:
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PMID: 9561517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study, we found that the extent of necrosis was the only radiological feature which correlated significantly with survival in patients with glioblastoma. The aim of this paper was to evaluate the variability and prognostic value of the extent of the necrotic area as seen on contrast-enhanced MRI and CT in a larger series. We studied 72 patients who underwent surgical removal of supratentorial glioblastomas and had CT and/or MRI with contrast medium before surgery; 38, all undergoing the same treatment (surgery plus radiotherapy), were followed clinically. Necrosis within the tumour varied greatly, ranging from none (only 1 case) to involvement of 76% of the tumour. Survival data in the subgroup suggested that only patients with a small area of necrosis (less than 35% of the tumour) had a significantly longer survival time. When necrosis involved more than 35% of the mass, patients had a shorter survival time, without any further correlation with the extent of necrosis. |
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Authors:
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A Pierallini; M Bonamini; P Pantano; F Palmeggiani; M Raguso; M F Osti; G Anaveri; L Bozzao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroradiology Volume: 40 ISSN: 0028-3940 ISO Abbreviation: Neuroradiology Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-06-19 Completed Date: 1998-06-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: GERMANY |
Other Details:
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Languages: eng Pagination: 150-3 Citation Subset: IM |
Affiliation:
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Department of Neurological Sciences, University of Rome La Sapienza, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Combined Modality Therapy Contrast Media Female Gadolinium DTPA / diagnostic use Glioblastoma / diagnosis*, mortality, therapy Humans Magnetic Resonance Imaging / methods* Male Middle Aged Necrosis Prognosis Supratentorial Neoplasms / diagnosis*, mortality, therapy Survival Analysis Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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