| Radiological features of Pneumocystis jirovecii Pneumonia in immunocompromised patients with and without AIDS. | |
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MedLine Citation:
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PMID: 20049469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare chest computerized tomography (CT) findings of Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients with and without acquired immune deficiency syndrome (AIDS). Chest CT findings and clinical parameters of 38 consecutive immunocompromised patients, nine with AIDS and 29 with other causes of immunosuppression, were characterized and compared. PCP in patients without AIDS was diagnosed after a significantly shorter time interval from symptom onset: 8 +/- 6 vs. 18 +/- 1.0 days (p = 0.024). From a radiographic point of view, non-AIDS patients had a significantly higher proportion of diffuse ground glass lesions, 86 vs. 44% (p = 0.02), and a lower proportion of cystic lesions, 3 vs. 56% (p = 0.015). The two subgroups did not differ in smoking status and the number of pack-years. On multivariant analysis, only the presence of AIDS was found to be a risk factor for the formation of pulmonary cystic lesions. Different immune reactions to the parasite P. jirovecii in immunocompromised patients with and without AIDS results in a different time lag between symptoms and a correspondingly different radiographic pattern: widespread ground glass opacities in the former and cystic lesions in the latter. |
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Authors:
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Emilia Hardak; Olga Brook; Mordechai Yigla |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-01-05 |
Journal Detail:
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Title: Lung Volume: 188 ISSN: 1432-1750 ISO Abbreviation: Lung Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: United States |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: IM |
Affiliation:
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Division of Pulmonary Medicine, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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immunology,
microbiology,
radiography* Adult Aged Cysts / immunology, microbiology, radiography*, virology Female Humans Immunocompromised Host* Lung / immunology, microbiology, radiography*, virology Male Middle Aged Pneumocystis jirovecii / pathogenicity* Pneumonia, Pneumocystis / immunology, microbiology, radiography* Predictive Value of Tests Retrospective Studies Risk Assessment Risk Factors Smoking / adverse effects Tomography, X-Ray Computed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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