| Radiological Contrast Media and Pancreatic Blood Perfusion in Anesthetized Rats. | |
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MedLine Citation:
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PMID: 17963084 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Radiological contrast media (CM) have been suggested to be able to impair pancreatic microcirculation. Purpose: To evaluate the effects of an iso-osmolar (iodixanol, 290 mOsm/kg H(2)O) and a low-osmolar (iopromide, 660 mOsm/kg H(2)O) CM on total pancreatic and islet blood perfusion. Material and Methods: Thiobutabarbital-anesthetized rats were injected with iodine-equivalent doses (600 mg I/kg body weight) of iodixanol or iopromide. Saline or low-osmolar mannitol (660 mOsm/kg H(2)O) solutions served as control substances. Blood perfusion measurements were then carried out with a microsphere technique. Results: Iso-osmolar iodixanol had no effects on blood perfusion. Low-osmolar iopromide increased total pancreatic blood perfusion, whereas islet blood perfusion was unchanged. No differences were seen when mannitol solutions were given. Conclusion: Neither an iso-osmolar nor a low-osmolar CM affected pancreatic islet blood perfusion, whereas the low-osmolar CM increased total pancreatic blood perfusion. The absence of hemodynamic effect of low-osmolar mannitol suggests that the hyperosmolality per se of iopromide versus iodixanol does not induce the hemodynamic effect. The consequences of the effect of iopromide for pancreatic function remain to be established. |
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Authors:
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G Linder; P-O Carlsson; O Källskog; P Hansell; L Jansson; V Riesenfeld Källskog |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2007-10-24 |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: - ISSN: 1600-0455 ISO Abbreviation: Acta Radiol Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: - |
Other Details:
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Languages: ENG Pagination: 1-5 Citation Subset: - |
Affiliation:
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Department of Medical Cell Biology and Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Department of Radiology, Karolinska University Hospital, Solna, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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