| Radiologic progression during intramuscular methotrexate treatment of rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 2084237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The radiographic evolution of joint lesions in 41 patients with severe and longstanding rheumatoid arthritis (RA) (mean duration: 12.9 years) treated with methotrexate (MTX) for more than 24 months (mean 31.2 months) was studied in a double blind manner by 2 rheumatologists using Larsen's score. All the patients were clinically improved. The radiological study of hands and wrists was possible in only 37 of 41 patients for surgical reasons. We found a deterioration of joint lesions in 31 cases (83.8%), a stabilization in 6 cases (16.2%). MTX does not appear to be able to slow down the radiographic evolution of RA. Whether it could prevent the radiologic progression in early RA remains to be elucidated. |
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Authors:
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J Sany; S Kaliski; M Couret; M Cuchacovich; J P Daures |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 17 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-05-16 Completed Date: 1991-05-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1636-41 Citation Subset: IM |
Affiliation:
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Service d'Immuno-Rhumatologie, CHU, Montpellier, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthritis, Rheumatoid / drug therapy*, pathology, radiography Arthrography Double-Blind Method Female Humans Injections, Intramuscular Joint Diseases / pathology, radiography Joints / pathology Male Methotrexate / administration & dosage, therapeutic use* Middle Aged Time Factors |
| Chemical | |
Reg. No./Substance:
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59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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