Document Detail


Radiologic phenotypes in lumbar MR imaging for a gene defect in the COL9A3 gene of type IX collagen.
MedLine Citation:
PMID:  12601188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate whether the COL9A3 tryptophan allele (Trp3 allele) is associated with a specific radiologic phenotype among patients with sciatica. MATERIALS AND METHODS: One hundred fifty-three patients with sciatica were evaluated for the presence of Trp3 allele, Scheuermann disease, intervertebral disk degeneration, Schmorl nodules, dorsal anular tears, hyperintense lesions, and endplate degeneration on sagittal T2-weighted lumbar magnetic resonance images. The Trp3 genotype was determined by means of sequencing the COL9A3 gene. Radiologic phenotypes were evaluated while blinded to the genotype. Scheuermann disease was diagnosed if either endplate irregularities or Schmorl nodules and two of the other three criteria (disk space narrowing, disk dehydration, and wedging of anterior vertebral body margins) were present at three or more adjacent disk levels from T10-11 to L3-4. Disk degeneration was evaluated separately for each disk (T11-12 to L5-S1) and for all disks combined. Frequencies of radiologic phenotypes between individuals with or without Trp3 allele were compared. RESULTS: Thirty-four patients had at least one Trp3 allele. When compared with the matched control subjects, they had an increased likelihood of Scheuermann disease (P =.035) and an increased number of degenerated disks from T11 to S1 (P =.021). Comparisons at individual disks showed a statistically significant increase in disk degeneration at T11-12 (analysis of all grades of degeneration [graded], P =.018; analysis of any degeneration vs none [dichotomous], P =.039) and L4-5 (graded, P =.011; dichotomous, P =.016). Prevalences of anular tears, endplate degeneration, Schmorl nodules, and hyperintense lesions were comparable. CONCLUSION: The results of this study indicate that the presence of Trp3 allele is associated with Scheuermann disease and intervertebral disk degeneration. No associations were found for other radiologic phenotypes.
Authors:
Jaro Karppinen; Eija Pääkkö; Petteri Paassilta; Jaana Lohiniva; Mauno Kurunlahti; Osmo Tervonen; Pentti Nieminen; Harald H H Göring; Antti Malmivaara; Heikki Vanharanta; Leena Ala-Kokko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-02-19
Journal Detail:
Title:  Radiology     Volume:  227     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, University Hospital of Oulu, PL 25, FIN-90029 Oulu, Finland. jaro.karppinen@ttl.fi
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MeSH Terms
Descriptor/Qualifier:
Collagen Type IX / genetics*
Female
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Phenotype
Grant Support
ID/Acronym/Agency:
AR45982/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/COL9A3 protein, human; 0/Collagen Type IX

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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