| Radiologic findings in patients treated with boron neutron capture therapy for glioblastoma multiforme within EORTC trial 11961. | |
| | |
MedLine Citation:
|
PMID: 15667958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To assess the occurrence and development of cerebral radiologic changes (cerebral atrophy and white matter lesions) in patients treated with boron neutron capture therapy (BNCT) for primary supratentorial glioblastoma multiforme within the European Organization for Research and Treatment of Cancer (EORTC) trial 11961. METHODS AND MATERIALS: Magnetic resonance imaging (MRI) scans were performed before and after surgery and at 1 week and 2, 4.5, 6, 9, 12, 15, and 18 months after BNCT. For the current study, MRI scans of all assessable patients were analyzed, with emphasis on cerebral atrophy and white matter abnormalities. RESULTS: Twenty-six patients had been treated with BNCT according to the EORTC trial 11961, of whom 24 were assessable for the current study. The development of possible BNCT-related cerebral changes was observed in 12 patients (50%), 10 of whom had cerebral atrophy (42%) and 10 white matter changes (42%) after a median interval of 7.5 and 4.5 months, respectively. CONCLUSION: In this study, cerebral radiologic changes appeared in 50% of patients within the first year after BNCT. Although a clear correlation between the BNCT dose and the development of cerebral changes could not be demonstrated, a relationship between the occurrence of these radiologic abnormalities and BNCT seems likely. |
| | |
Authors:
|
Maaike J Vos; Bernd Turowski; Friedhelm E Zanella; Philippe Paquis; Axel Siefert; Katalin Hideghéty; Klaus Haselsberger; Frank Grochulla; Tjeerd J Postma; Andrea Wittig; Jan J Heimans; Ben J Slotman; W Peter Vandertop; Wolfgang Sauerwein |
Related Documents
:
|
1553038 - Mri of patients with cerebral palsy and normal ct scan. 15947768 - Incidence of cerebral embolism after cardioversion of atrial fibrillation: a prospectiv... 16342908 - Evaluation of optimal scan duration and end time in cerebral ct perfusion study. 1595458 - Cerebral infarction: assessment of patterns using ultra-fast mr contrast imaging. 2583198 - Online brain attenuation correction in pet: towards a fully automated data handling in ... 8873338 - The clinical measurement of volumes using helical ct. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: 61 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-01-25 Completed Date: 2005-03-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
|
Languages: eng Pagination: 392-9 Citation Subset: IM |
Affiliation:
|
Department of Neurology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands. mj.vos@vumc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Atrophy / etiology, pathology Boron Neutron Capture Therapy / adverse effects* Brain / pathology, radiation effects* Brain Neoplasms / radiotherapy* Clinical Trials as Topic Female Glioblastoma / radiotherapy* Humans Magnetic Resonance Imaging Male Middle Aged Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Postoperative radiation therapy for grade II and III intracranial ependymoma.
Next Document: A dose-escalation trial with the adaptive radiotherapy process as a delivery system in localized pro...