| Radiolabelling and biodistribution of 111In-antimony trisulphide colloid. | |
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MedLine Citation:
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PMID: 16142252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to prepare 111In-antimony trisulphide colloid (111In-ATC) and evaluate its chemical properties in comparison with 99mTc-ATC. After reconstitution of an antimony trisulphide cold Kit with 111In-chloride, 111In-ATC was formed with >95% radiochemical purity in the presence of neutralising phosphate buffer. The product was found to be stable for 4.7 days when stored at room temperature, 80% of radioactive particles were < 20 nm in diameter and the mouse biodistribution assay was identical to that of 99mTc-ATC. In conclusion, pharmaceutical-grade 111In-ATC was successfully prepared and assessed to have properties that are suitable for dual-isotope lymphoscintigraphy studies at the clinical level. |
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Authors:
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Chris Tsopelas; Robert Cooper |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Hellenic journal of nuclear medicine Volume: 8 ISSN: 1790-5427 ISO Abbreviation: Hell J Nucl Med Publication Date: 2005 May-Aug |
Date Detail:
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Created Date: 2005-09-05 Completed Date: 2005-12-14 Revised Date: 2010-08-23 |
Medline Journal Info:
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Nlm Unique ID: 101257471 Medline TA: Hell J Nucl Med Country: Greece |
Other Details:
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Languages: eng Pagination: 109-12 Citation Subset: IM |
Affiliation:
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RAH Radiopharmacy, Royal Adelaide Hospital, Nuclear Medicine Department, North Terrace, Adelaide, 5000, Australia. ctsopela@mail.rah.sa.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimony / chemistry*, diagnostic use, pharmacokinetics* Colloids / chemistry*, pharmacokinetics* Drug Stability Liver / metabolism*, radionuclide imaging Lung / metabolism*, radionuclide imaging Metabolic Clearance Rate Mice Organ Specificity Particle Size Radiopharmaceuticals / chemical synthesis, diagnostic use, pharmacokinetics Spleen / metabolism*, radionuclide imaging Technetium Compounds / diagnostic use, pharmacokinetics Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Colloids; 0/Radiopharmaceuticals; 0/Technetium Compounds; 0/technetium Tc 99m antimony sulfide; 7440-36-0/Antimony |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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