Document Detail

Radiolabelled anti-human fibrin antibody: a new thrombus-detecting agent.
MedLine Citation:
PMID:  65564     Owner:  NLM     Status:  MEDLINE    
Rabbit anti-human fibrin globulin (A.F.G.) was labelled with iodine (131I) and used as a thrombus-detecting agent. 131I-A.F.G. labelled thrombi were displayed by means of a gamma scintillation camera. Normal subjects and patients with thrombophlebitis of legs, acute fibrin depositions other than thrombi, and chronic varicosities were examined. The 131I-A.F.G. technique detected both formed thrombi and those that were forming and could discriminate between acute thrombosis and chronic varicosities. Thrombophlebitis and extravascular fibrin depositions were best demonstrated between 24 and 27 hours of 131I-A.F.G. injection. Radiolabelled A.F.G. in normal veins and chronic varicosities was best displayed within 6 hours of injection.
V B Bosnjaković; B D Janković; J Horvat; J Cvoric
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  452-4     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Chronic Disease
Diagnosis, Differential
Fibrin / immunology*
Iodine Radioisotopes
Isotope Labeling
Middle Aged
Radionuclide Imaging*
Thrombophlebitis / diagnosis*
Time Factors
Varicose Veins / diagnosis
Reg. No./Substance:
0/Antibodies; 0/Iodine Radioisotopes; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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