| Radiolabeling of folic acid-modified chitosan with (99m)Tc as potential agents for folate-receptor-mediated targeting. | |
| | |
MedLine Citation:
|
PMID: 21920738 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The feasibility of chitosan (CS) as a backbone for the design of (99m)Tc-labeled targeting agent was evaluated in this study. Chitosan-folate conjugate (CSFA) and chitosan-folate dithiocarbamate (CSFADTC) were synthesized, characterized and radiolabeled with (99m)Tc as model compounds for folate-receptor (FR) targeting. (99m)Tc-complexes were prepared with high radiochemical purity and high stability. The hydrophilicities of these (99m)Tc-complexes were determined by partition coefficient experiments. The results of biodistribution in normal mice showed that the folic-acid modified agents ((99m)Tc-CSFA and (99m)TcN-CSFADTC) had obviously higher uptake in FR-positive kidney and much lower liver and spleen uptakes than that of non-folic-acid modified (99m)Tc-agent, and the kidney uptakes of FA-modified agents could be blocked significantly by the corresponding cold ligand. Furthermore in vitro and in vivo specific studies will be done in cell line and tumor bearing mice to confirm the usefulness of this chitosan backbone for FR targeting agent design. |
| | |
Authors:
|
Wenyan Guo; Huihui Jing; Wenjiang Yang; Zhide Guo; Shi Feng; Xianzhong Zhang |
Related Documents
:
|
16871058 - Postoperative infusion of amino acids induces a positive protein balance independently ... 14086108 - Effect of alanine and threonine on the synthesis of serine by leuconostoc mesenteroides. 3348378 - Ammonia production from intraluminal amino acids in canine jejunum. 7411238 - Total aromatic amino acid requirement, phenylalanine requirement and tyrosine replaceme... 8957218 - Modulation of tyrosine hydroxylase and aromatic l-amino acid decarboxylase after inhibi... 1322178 - The effects of the phospholipase a2 inhibitors aristolochic acid and pgbx on a23187-sti... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-24 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-9-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer St., Beijing 100875, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, Fc...
Next Document: Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new...