| Radiolabeled monoclonal antibodies against Reed-Sternberg cells for in vivo imaging of Hodgkin's disease by immunoscintigraphy. | |
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MedLine Citation:
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PMID: 2602643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Hodgkin Reed-Sternberg (HRS-1) monoclonal antibody (Mab) was raised against the L 428 Hodgkin's disease (HD) cell line. The HRS-1 Mab was labeled with radioactive iodine and injected into six patients with Hodgkin's disease of varied histological subtypes for immunoscintigraphic imaging. In five patients, the HRS-1 Mab was labeled with 131I; a control anti-alpha-fetoprotein (AFP) Mab was injected simultaneously in two of these five cases. Four of five patients had a positive scan (nodal, splenic and hepatic involvements), the results in the fifth patient being equivocal. In the sixth patient, the HRS-1 Mab was labeled with 123I in order to utilize tomoscintigraphy instead of linear scintigraphy. Although the immunoscintigraphy (IS) was performed secondary to effective chemotherapy, images of bony disease were demonstrated. These preliminary results demonstrate that IS with iodine-labeled HRS-1 Mab is feasible and informative in Hodgkin's lymphoma. The real clinical value and the specificity of IS deserves confirmation in a larger series of patients. Several techniques such as the use of Fab or F(ab')2 fragments should further improve the results. |
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Authors:
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P Carde; M Pfreundschuh; L da Costa; L Manil; J D Lumbroso; B Caillou; C Parmentier; J C Saccavini; V Diehl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer Volume: 117 ISSN: 0080-0015 ISO Abbreviation: Recent Results Cancer Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-02-01 Completed Date: 1990-02-01 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0044671 Medline TA: Recent Results Cancer Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 101-11 Citation Subset: IM |
Affiliation:
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Institut Gustave-Roussy, Villejuif, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Antibodies, Monoclonal / diagnostic use* Bone and Bones / radionuclide imaging Female Hodgkin Disease / immunology, pathology, radionuclide imaging* Humans Iodine Radioisotopes / diagnostic use Lymph Nodes / radionuclide imaging Male Mediastinum / radionuclide imaging Mice Mice, Inbred BALB C Middle Aged Spleen / radionuclide imaging Tomography |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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