Document Detail


Radiolabeled monoclonal antibodies against Reed-Sternberg cells for in vivo imaging of Hodgkin's disease by immunoscintigraphy.
MedLine Citation:
PMID:  2602643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Hodgkin Reed-Sternberg (HRS-1) monoclonal antibody (Mab) was raised against the L 428 Hodgkin's disease (HD) cell line. The HRS-1 Mab was labeled with radioactive iodine and injected into six patients with Hodgkin's disease of varied histological subtypes for immunoscintigraphic imaging. In five patients, the HRS-1 Mab was labeled with 131I; a control anti-alpha-fetoprotein (AFP) Mab was injected simultaneously in two of these five cases. Four of five patients had a positive scan (nodal, splenic and hepatic involvements), the results in the fifth patient being equivocal. In the sixth patient, the HRS-1 Mab was labeled with 123I in order to utilize tomoscintigraphy instead of linear scintigraphy. Although the immunoscintigraphy (IS) was performed secondary to effective chemotherapy, images of bony disease were demonstrated. These preliminary results demonstrate that IS with iodine-labeled HRS-1 Mab is feasible and informative in Hodgkin's lymphoma. The real clinical value and the specificity of IS deserves confirmation in a larger series of patients. Several techniques such as the use of Fab or F(ab')2 fragments should further improve the results.
Authors:
P Carde; M Pfreundschuh; L da Costa; L Manil; J D Lumbroso; B Caillou; C Parmentier; J C Saccavini; V Diehl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  117     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-01     Completed Date:  1990-02-01     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  101-11     Citation Subset:  IM    
Affiliation:
Institut Gustave-Roussy, Villejuif, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Antibodies, Monoclonal / diagnostic use*
Bone and Bones / radionuclide imaging
Female
Hodgkin Disease / immunology,  pathology,  radionuclide imaging*
Humans
Iodine Radioisotopes / diagnostic use
Lymph Nodes / radionuclide imaging
Male
Mediastinum / radionuclide imaging
Mice
Mice, Inbred BALB C
Middle Aged
Spleen / radionuclide imaging
Tomography
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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