| Radiolabeled glucocorticoids as molecular probes for imaging brain glucocorticoid receptors by means of positron emission tomography (PET). | |
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MedLine Citation:
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PMID: 18537728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the last two decades, numerous attempts have been made to develop (11)C- and (18)F-labeled radiotracers in order to study glucocorticoid receptor (GR)-mediated abnormalities of the hypothalamus-pituitary-adrenocortical (HPA) axis function and regulation in vivo by means of positron emission tomography (PET). The present review addresses the research efforts dealing with the design, radiosynthesis and radiopharmacological evaluation of PET radiotracers for brain GR imaging. The underlying problems such as metabolic instability, insufficient blood-brain-barrier penetration and/or high non-specific binding will be discussed. |
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Authors:
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Björn Steiniger; Torsten Kniess; Ralf Bergmann; Jens Pietzsch; Frank R Wuest |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: 8 ISSN: 1389-5575 ISO Abbreviation: Mini Rev Med Chem Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-09 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 728-39 Citation Subset: IM |
Affiliation:
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Institute of Radiopharmacy, Research Center Dresden-Rossendorf, D-01314 Dresden, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / radionuclide imaging* Glucocorticoids / chemical synthesis*, chemistry, pharmacokinetics Molecular Probes / chemical synthesis, chemistry, pharmacokinetics Positron-Emission Tomography* Radiopharmaceuticals / chemical synthesis*, chemistry, pharmacokinetics Receptors, Glucocorticoid / analysis*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Molecular Probes; 0/Radiopharmaceuticals; 0/Receptors, Glucocorticoid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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