| Radiolabeled glucagon-like peptide-1 analogues: a new pancreatic β-cell imaging agent. | |
| | |
MedLine Citation:
|
PMID: 22262216 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Glucagon-like peptide-1 (GLP-1) is a potent antihyperglycemic hormone. It can induce glucose-dependent insulin secretion. GLP-1 has a short half-life of less than 2 min in vivo due to degradation by the dipeptidyl peptidase-IV. GLP-l analogues, such as exendin-4 and exendin-3, have similar biological activity but a longer in-vivo half-life. Pancreatic β-cells and pancreatic islet cell tumors highly express GLP-1 receptors. Hence, radiolabeled GLP-1 analogues play a potential role in imaging and radiation therapy of pancreatic islet cell tumors as well as in the monitoring of pancreatic β-cell transplantation. |
| | |
Authors:
|
Yifan Zhang; Wengen Chen |
Related Documents
:
|
7573456 - Nerve growth factor synthesis by intestinal epithelial cells. 17161396 - Chloroquine-induced endocytic pathway abnormalities: cellular model of gm1 ganglioside-... 20578246 - Neurite outgrowth from pc12 cells by basic fibroblast growth factor (bfgf) is mediated ... 9535116 - No is not involved in the simvastatin induced cell division and differentiation in pc12... 12907656 - The role of transforming growth factor alpha in determining growth factor independence. 18488416 - Adverse effects of fullerenes on endothelial cells: fullerenol c60(oh)24 induced tissue... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Nuclear medicine communications Volume: 33 ISSN: 1473-5628 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: - |
Other Details:
|
Languages: ENG Pagination: 223-227 Citation Subset: - |
Affiliation:
|
aDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China bDiagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Samplers for VOCs in air based on cyclodextrin-silica hybrid microporous solid phases.
Next Document: Bacillus cereus Infection After Descemet Stripping Endothelial Keratoplasty.