Document Detail

Radiolabeled fiber: a physiologic marker for gastric emptying and intestinal transit of solids.
MedLine Citation:
PMID:  7353464     Owner:  NLM     Status:  MEDLINE    
We report here a study of radiolabeled cellulose as a marker for gastric emptying and intestinal transit of fiber in a dog model. A chemically stable radioisotopic label (131I) was employed to facilitate external monitoring of the tracer. 131I-labeled fiber was found to be biologically stable, since no iodine was absorbed during passage through the canine digestive system. In comparison with water-soluble tracers, gastric emptying of [131I]fiber is very slow. This is consistent with the expected behavior of fiber as a nondigestible solid. We anticipate this new radiolabeled marker will prove to be a useful tool for studies on gastric emptying, intestinal transit, fate and actions of dietary fiber in nonruminant experimental animals and, eventually, in man.
J R Malagelada; S E Carter; M L Brown; G L Carlson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  25     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-04-25     Completed Date:  1980-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-7     Citation Subset:  AIM; IM    
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MeSH Terms
Dietary Fiber*
Feces / analysis
Gastric Emptying*
Intestines / physiology*
Iodine Radioisotopes / diagnostic use*
Isotope Labeling
Reg. No./Substance:
0/Iodine Radioisotopes; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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