Document Detail

Radioisotopic pacemaker: long-term clinical results.
MedLine Citation:
PMID:  7731876     Owner:  NLM     Status:  MEDLINE    
In order to prolong the service life of the generator, the isotopic pacemakers, powered by Pu238, have been developed and implanted since 1970. We report the follow-up of 325 patients (mean age 39 +/- 18 years) implanted with an isotopic pulse generator (Medtronic 9000/9090) between April 1970 and July 1982. The mean follow-up was 12 years (range 6 days to 18.5 years). The generator was highly reliable; the mean value of pacing rate between implantation and last follow-up decreased significantly but no more than 1 beat/min (72.7 vs 71.8 beats/min; P < 0.001) and the pulse width did not change significantly. The actuarial survival of the device was 97% at 18.5 years. During the follow-up period, 122 reoperations were performed in 85 patients: 88 explanations of the entire pacing system and 34 modifications of the lead system. Lead dysfunction accounted for 68% of the 122 reoperations, generator failure for 6%, and miscellaneous reasons for 26%. However, 72% of patients remain free of intervention during the follow-up period and 61 patients (20%) died during this period. Most deaths (52%) were of nonsudden cardiovascular origin, 17% were related to cancer, and 13% to sudden death. After 5, 10, and 18.5 years, 94%, 89%, and 73% of the patients were alive, respectively. No side effect could be attributed to the radioisotope. We conclude that this isotopic pacemaker demonstrated its reliability for long-term cardiac pacing.
C Chauvel; T Lavergne; A Cohen; P Ducimetière; J Y Le Heuzey; J Valty; L Guize
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  18     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-30     Completed Date:  1995-05-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  286-92     Citation Subset:  IM    
Cardiology Department, Saint-Antoine University Hospital, Paris, France.
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MeSH Terms
Actuarial Analysis
Arrhythmia, Sinus / epidemiology,  therapy*
Electric Power Supplies
Electrodes, Implanted / statistics & numerical data
Equipment Design
Follow-Up Studies
Heart Block / epidemiology,  therapy*
Pacemaker, Artificial* / statistics & numerical data
Time Factors
Reg. No./Substance:

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