Document Detail

Radioiodine therapy of Graves' hyperthyroidism in patients without pre-existing ophthalmopathy: can glucocorticoids prevent the development of new ophthalmopathy?
MedLine Citation:
PMID:  16915539     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Radioiodine therapy (RIT) combined with glucocorticoids is an effective therapy for Graves' disease, but it is debatable whether glucocorticoids should be applied in patients without Graves' ophthalmopathy (GO). METHODS: The effect of 0.4 - 0.5 mg prednisone every second day over a period of 5 weeks after RIT was monitored over a follow-up period of at least 12 months after RIT. A questionnaire was sent to 186 consecutive patients without GO concerning eye symptoms after RIT. 148 patients (80 %) answered. If eye symptoms had occurred after RIT, additional clinical examination was carried out at our outpatient clinic. The primary endpoint was the absence or onset of GO within the first year after RIT. RESULTS: Within 12 months after RIT the examination confirmed GO in 5 out of 148 patients (3.4 %). In all cases the symptoms were transient. No adverse reaction to the use of prednisone after RIT was noted. CONCLUSIONS: The risk of new GO in the first year after RIT was low and the clinical course of GO was mild when RIT was combined with a low-dose glucocorticoid regimen. Preventive administration of glucocorticoids can therefore be recommended in patients with Graves' disease even without evident GO.
B Dederichs; M Dietlein; B Jenniches-Kloth; M Schmidt; P Theissen; D Moka; H Schicha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  114     ISSN:  0947-7349     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-17     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  366-70     Citation Subset:  IM    
Department of Nuclear Medicine, University of Cologne, Germany.
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MeSH Terms
Follow-Up Studies
Glucocorticoids / therapeutic use*
Graves Disease / radiography*
Graves Ophthalmopathy / epidemiology,  prevention & control*
Iodine Radioisotopes / therapeutic use*
Middle Aged
Patient Selection
Prednisone / therapeutic use*
Radiopharmaceuticals / therapeutic use
Risk Assessment
Reg. No./Substance:
0/Glucocorticoids; 0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 53-03-2/Prednisone

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