Document Detail


Radioiodine therapy of Graves' hyperthyroidism in patients without pre-existing ophthalmopathy: can glucocorticoids prevent the development of new ophthalmopathy?
MedLine Citation:
PMID:  16915539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Radioiodine therapy (RIT) combined with glucocorticoids is an effective therapy for Graves' disease, but it is debatable whether glucocorticoids should be applied in patients without Graves' ophthalmopathy (GO). METHODS: The effect of 0.4 - 0.5 mg prednisone every second day over a period of 5 weeks after RIT was monitored over a follow-up period of at least 12 months after RIT. A questionnaire was sent to 186 consecutive patients without GO concerning eye symptoms after RIT. 148 patients (80 %) answered. If eye symptoms had occurred after RIT, additional clinical examination was carried out at our outpatient clinic. The primary endpoint was the absence or onset of GO within the first year after RIT. RESULTS: Within 12 months after RIT the examination confirmed GO in 5 out of 148 patients (3.4 %). In all cases the symptoms were transient. No adverse reaction to the use of prednisone after RIT was noted. CONCLUSIONS: The risk of new GO in the first year after RIT was low and the clinical course of GO was mild when RIT was combined with a low-dose glucocorticoid regimen. Preventive administration of glucocorticoids can therefore be recommended in patients with Graves' disease even without evident GO.
Authors:
B Dederichs; M Dietlein; B Jenniches-Kloth; M Schmidt; P Theissen; D Moka; H Schicha
Related Documents :
15521969 - Long-term follow-up study of radioiodine treatment of hyperthyroidism.
3304509 - Ultrasonically guided percutaneous inactivation of parathyroid tumours.
7324739 - Complications to subtotal parathyroidectomy.
10668879 - Long-term results of subcutaneous parathyroid grafts in uremic patients.
8484389 - Case report: silent thyroiditis after adrenalectomy in a patient with cushing's syndrome.
11676109 - Role of surgery in the management of graves' disease.
3171849 - Paraesophageal hernia after nissen fundoplication: a real complication in pediatric pat...
3711609 - Wrist arthrodesis.
15791029 - Late restenosis of the balloon-dilated site: serial angiographic observations beyond 7 ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  114     ISSN:  0947-7349     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-17     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  366-70     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, University of Cologne, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Female
Follow-Up Studies
Glucocorticoids / therapeutic use*
Graves Disease / radiography*
Graves Ophthalmopathy / epidemiology,  prevention & control*
Humans
Iodine Radioisotopes / therapeutic use*
Male
Middle Aged
Patient Selection
Prednisone / therapeutic use*
Questionnaires
Radiopharmaceuticals / therapeutic use
Risk Assessment
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Small neuroendocrine pancreatic tumors in multiple endocrine neoplasia type 1 (MEN1): least signific...
Next Document:  Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome.