Document Detail

Radioiodine ablation of residual tissue in thyroid cancer: relationship between administered activity, neck uptake and outcome.
MedLine Citation:
PMID:  7820407     Owner:  NLM     Status:  MEDLINE    
A retrospective review was performed to evaluate the effectiveness of radioiodine in the ablation of residual thyroid tissue after surgery for differentiated thyroid cancer. 121 patients were treated at the Princess Margaret Hospital, Toronto, Canada between 1977 and 1989, with the activity of radioiodine determined empirically. Ablation of residual thyroid was determined by 131I nuclear scans, using absent visible uptake (compared with background) as the criterion for successful ablation. 97 patients (80%) had successful ablation of residual thyroid tissue after the first administration of radioiodine. Patients with higher iodine uptake in the neck had a tendency to receive higher activities of 131I. There were no statistically significant differences in age, sex, type of surgery, initial iodine uptake in the neck and administered radioiodine activity between those successfully ablated and those that were not. Patients receiving less than 3.7 GBq (100 mCi) tended to have lower iodine uptake (< 5% at 24 or 48 h), but their rate of thyroid ablation was just as high as those given 3.7 GBq or more. In order to take advantage of this, we have formalized our approach by deriving guidelines to the empiric determination of radioiodine activity based on the iodine uptake in the neck. Among the 11 patients treated with lobectomy only, the ablation rate was 64%. Although this was not significantly lower than for other forms of surgery, we continue to recommend completion thyroidectomy for this group of patients, if the goal of treatment is to ablate all thyroid tissue.
J P Logue; R W Tsang; J D Brierley; W J Simpson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of radiology     Volume:  67     ISSN:  0007-1285     ISO Abbreviation:  Br J Radiol     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-02-16     Completed Date:  1995-02-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1127-31     Citation Subset:  AIM; IM    
Department of Radiation Oncology, University of Toronto, Ontario Cancer Institute/Princess Margaret Hospital, Canada.
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MeSH Terms
Aged, 80 and over
Iodine Radioisotopes / pharmacokinetics,  therapeutic use*
Middle Aged
Neoplasm, Residual
Radiotherapy Dosage
Radiotherapy, Adjuvant
Retrospective Studies
Thyroid Neoplasms / metabolism,  radiotherapy*,  surgery
Treatment Outcome
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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