| Radioiodinated alpha-p-iodophenyl-N-tert-butylnitrone as a radical detecting agent in vivo. | |
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MedLine Citation:
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PMID: 9290074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For in vivo detection of unstable radical species, a novel radioiodinated radical trapping agent, alpha-p-iodophenyl-N-tert-butylnitrone (IPBN), was designed based on the plausible characteristics of alpha-p-hydroxy-m-iodophenyl-N-tert-butylnitrone (HIPBN). Both compounds are iodinated analogs of alpha-phenyl-N-tert-butylnitrone (PBN), but the latter showed low stability in vivo. The present compound IPBN was easily prepared and labeled with radioiodine. It showed very stable characteristics in vitro as well as in vivo, but was easily metabolized and retained at sites of superoxide production. |
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Authors:
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Y Fujibayashi; N Tajima; K Wada; A Waki; H Sakahara; J Konishi; A Yokoyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 24 ISSN: 0969-8051 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1998-01-14 Completed Date: 1998-01-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 399-403 Citation Subset: IM |
Affiliation:
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Department of Radiopharmaceutical Chemistry, Fukui Medical School, Japan. yfuji@pharm.kyoto-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclic N-Oxides Drug Stability Free Radicals Humans Iodine Radioisotopes / diagnostic use* Male Mice Nitrogen Oxides / pharmacokinetics* Superoxides / metabolism* Tissue Distribution Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Cyclic N-Oxides; 0/Free Radicals; 0/Iodine Radioisotopes; 0/Nitrogen Oxides; 11062-77-4/Superoxides; 3376-24-7/phenyl-N-tert-butylnitrone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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