Document Detail


Radioimmunoguided breast surgery using radiolabeled antibody NR-LU-10 FAB: a pilot study.
MedLine Citation:
PMID:  11504368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM AND BACKGROUND: Radioimmunoguided surgery using radiolabeled NR-LU-10 Fab was evaluated as a method of intraoperative breast cancer detection. METHODS: Breast cancer patients were injected intravenously with 125I (74 MBq) labeled NR-LU-10 Fab (5 mg) and then underwent tumor excision 2, 4 or 7 days later, during which time the gamma detector probe was used to evaluate the primary tumor for evidence of radioactive uptake. RESULTS: Intraoperative probing revealed tumor localization in 7 of 10 patients (70%). Gamma probe counts of the excised tumor were elevated in all patients, although high counts in surrounding non-malignant tissue obscured the ability to detect the tumor in vivo in 3 patients. One patient with bilateral breast cancer was found to have a separate focus of occult tumor in each breast using the gamma detector probe. CONCLUSIONS: Radiolabeled NR-LU-10 Fab possesses favorable pharmokinetics and tumor-binding ability as a targeting agent. However, binding to non-malignant tissue limits its role in the intraoperative evaluation of tumor margins in breast cancer patients. Its role in other malignancies should be explored.
Authors:
W E Burak; L DePalatis; J L Mosic; D Soble; G Hinkle; C L Hitchcock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumori     Volume:  87     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-08-15     Completed Date:  2001-09-06     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  IM    
Affiliation:
Department of Surgery, The Ohio State University Comprehensive Cancer Center, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, USA. burak.1@osu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Monoclonal / diagnostic use*,  pharmacokinetics
Breast Neoplasms / blood,  radionuclide imaging*,  surgery*,  urine
Female
Humans
Injections
Iodine Radioisotopes / diagnostic use
Mastectomy, Segmental / methods*
Middle Aged
Pilot Projects
Radioimmunodetection / methods*
Time Factors
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Iodine Radioisotopes; 0/NR-LU-10 antibody

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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