Document Detail


Radioimmunoassay of serum myoglobin: evaluation and modification of a commercial kit and assessment of its usefulness for detecting acute myocardial infarction.
MedLine Citation:
PMID:  709846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated a modified procedure for a commercially available myoglobin radioimmunoassay kit (Nuclear Medical Systems). Within-run and run-to-run precision was acceptable. Normal ranges were established and paralelism studies performed. Clinical usefulness was assessed in 100 consecutive patients admitted to our coronary-care facility. The determinations were done daily, along with creatine kinase and its isoenzymes, and lactate dehydrogenase and its isoenzymes. Fifty of the 100 patients ultimately were shown to have had acute myocardial infarction. Myoglobinemia was present in most of the patients with acute myocardial infarction, but information on its presence was less usefull clinically than was detection of creatine kinase isoenzyme MB.
Authors:
N P Kubasik; W Guiney; K Warren; J P D'Souza; H E Sine; B B Brody
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  24     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-01-15     Completed Date:  1979-01-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2047-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Creatine Kinase / blood
Humans
Isoenzymes / blood
L-Lactate Dehydrogenase / blood
Myocardial Infarction / diagnosis*
Myoglobin / blood*
Radioimmunoassay
Reagent Kits, Diagnostic*
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Myoglobin; 0/Reagent Kits, Diagnostic; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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