| Radioimmunoassay of mouse vas deferens protein: developmental profile and hormonal regulation. | |
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MedLine Citation:
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PMID: 7852898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the hormonal regulation of the developmental pattern of a major protein of the mouse vas deferens (MVDP) which represents 10% of the vas deferens protein content. Using a specific radioimmunoassay, MVDP was first detected in 10-day-old males and its concentration increased sharply between 10 and 30 days, reaching adult levels at 40 days. In adult males, MVDP disappeared after castration, and testosterone treatment for 15 days was necessary to reverse the effect of castration completely. In 10-day-old mice castrated at birth, MVDP levels were similar to those measured in controls of the same age. Testosterone administration from 1 to 10 days of age did not induce precocious accumulation of MVDP. These results suggested that the neonatal expression of MVDP is independent of androgens. From 10 to 30 days, the increase in MVDP levels was androgen-dependent as shown by the castration and injection experiments. In males castrated at birth, the androgen-induced accumulation of MVDP was greatly reduced in adulthood. This suggested that neonatal androgens are necessary to obtain full expression of the MVDP gene in adults. |
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Authors:
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A Martinez; M Berger; C Jean-Faucher; G Veyssière; C Jean |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of endocrinology Volume: 138 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1995-03-10 Completed Date: 1995-03-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 99-105 Citation Subset: IM |
Affiliation:
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Physiologie Comparée et Endocrinologie CNRS URA 360, Université Blaise Pascal, Aubière, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
/
metabolism,
physiology Aldehyde Reductase* Androgens / physiology Animals Gene Expression Regulation, Developmental Genes Male Mice / growth & development, metabolism* Orchiectomy Proteins / analysis*, genetics, metabolism Radioimmunoassay Testosterone / pharmacology Vas Deferens / chemistry*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Proteins; 58-22-0/Testosterone; EC 1.1.1.21/Akrb7 protein, mouse; EC 1.1.1.21/Aldehyde Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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