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Radioimmunoassay of mammalian type C viral proteins. 3. Detection of viral antigen in normal murine cells and tissues.
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MedLine Citation:
PMID:  4347595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A radioimmunoassay specific for a murine leukemia virus structural protein, the gs antigen, detects an antigenic reactivity in normal murine cells in culture and natural tissues. The assay was shown to measure an antigen that is highly related to the virion protein as shown by absorption tests, immunoadsorbent chromatography, and by analysis of linearized dose-response curves. These findings combined with the finding of viral-specific RNA indicate that portions of the viral genome are being expressed with a much greater frequency than previously appreciated.
Authors:
W P Parks; D M Livingston; G J Todaro; R E Benveniste; E M Scolnick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  137     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1973 Mar 
Date Detail:
Created Date:  1973-05-01     Completed Date:  1973-05-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  622-35     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Viral / analysis*
Cell Line
Cells, Cultured / analysis
Chromatography, Affinity
Female
Humans
Iodine Isotopes
Kidney / immunology*
Leukemia Virus, Murine / immunology*
Liver / immunology*
Lymphoid Tissue / immunology*
Male
Mice
Mice, Inbred Strains
Nucleic Acid Hybridization
RNA, Viral / analysis
Radioimmunoassay
Rats
Rauscher Virus / immunology
Retroviridae / immunology
Thymidine
Tritium
Viral Proteins / analysis*
Chemical
Reg. No./Substance:
0/Antigens, Viral; 0/Iodine Isotopes; 0/RNA, Viral; 0/Viral Proteins; 10028-17-8/Tritium; 50-89-5/Thymidine
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1973 by The Rockefeller University Press
Received Day: 26 Month: 10 Year: 1972
Print publication date: Day: 28 Month: 2 Year: 1973
Volume: 137 Issue: 3
First Page: 622 Last Page: 635
ID: 2139374
PubMed Id: 4347595

RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES
Wade P. Parks
David M. Livingston
George J. Todaro
Raoul E. Benveniste
Edward M. Scolnick
From the Viral Carcinogenesis Branch and the Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014


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