|Radioimmunoassay of mammalian type C viral proteins. 3. Detection of viral antigen in normal murine cells and tissues.|
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|PMID: 4347595 Owner: NLM Status: MEDLINE|
|A radioimmunoassay specific for a murine leukemia virus structural protein, the gs antigen, detects an antigenic reactivity in normal murine cells in culture and natural tissues. The assay was shown to measure an antigen that is highly related to the virion protein as shown by absorption tests, immunoadsorbent chromatography, and by analysis of linearized dose-response curves. These findings combined with the finding of viral-specific RNA indicate that portions of the viral genome are being expressed with a much greater frequency than previously appreciated.|
|W P Parks; D M Livingston; G J Todaro; R E Benveniste; E M Scolnick|
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|Type: Journal Article|
|Title: The Journal of experimental medicine Volume: 137 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1973 Mar|
|Created Date: 1973-05-01 Completed Date: 1973-05-01 Revised Date: 2010-06-22|
Medline Journal Info:
|Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES|
|Languages: eng Pagination: 622-35 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Antigens, Viral / analysis*
Cells, Cultured / analysis
Kidney / immunology*
Leukemia Virus, Murine / immunology*
Liver / immunology*
Lymphoid Tissue / immunology*
Mice, Inbred Strains
Nucleic Acid Hybridization
RNA, Viral / analysis
Rauscher Virus / immunology
Retroviridae / immunology
Viral Proteins / analysis*
|0/Antigens, Viral; 0/Iodine Isotopes; 0/RNA, Viral; 0/Viral Proteins; 10028-17-8/Tritium; 50-89-5/Thymidine|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Journal ID (nlm-ta): J Exp Med
Publisher: The Rockefeller University Press
Copyright © 1973 by The Rockefeller University Press
Received Day: 26 Month: 10 Year: 1972
Print publication date: Day: 28 Month: 2 Year: 1973
Volume: 137 Issue: 3
First Page: 622 Last Page: 635
PubMed Id: 4347595
|RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES|
|Wade P. Parks|
|David M. Livingston|
|George J. Todaro|
|Raoul E. Benveniste|
|Edward M. Scolnick|
|From the Viral Carcinogenesis Branch and the Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
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