| Radioimmunoassay in diagnosis, localization and treatment of endocrine tumours in gut and pancreas. | |
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MedLine Citation:
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PMID: 225784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreas and gut hormones are involved in many endocrine and gastrointestinal diseases. Radioimmunoassays for these hormones have proved particularly valuable in diagnosis, localisation and control of treatment of endocrine tumours, of which many are mixed. An estimate based on ten years experience in a homogenous population of 5 million inhabitants (Denmark) suggests, that endocrine gut tumour-syndromes on an average appear with an incidence of 1 patient per year/syndrome/million. At present six different syndromes are known: 1) The insulinoma syndrome, 2) The Zollinger-Ellison syndrome.3) The Verner-Morrison syndrome. 4) The glucagonoma syndrome. 5) The somatostatinoma syndrome, and 6) the carcinoid syndrome. Accordingly diagnostically valuable RIAs for pancreas and gut hormones include those for insulin, gastrin, VIP, HPP, glucagon, somatostatin, and presumably also substance P. It is probably safe to predict that the need for gut and pancreas hormone RIAs within the next decade will increase greatly in order to assure proper management of tumours producing gastroentero-pancreatic hormones. |
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Authors:
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J F Rehfeld |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 53 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1979 |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 33-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma, Islet Cell
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blood Carcinoid Tumor / blood Cholecystokinin / blood Gastric Inhibitory Polypeptide / blood Gastrins / blood Gastrointestinal Hormones / blood* Glucagon / blood Glucagon-Like Peptides / blood Humans Insulin / blood Intestinal Neoplasms / blood* Motilin / blood Pancreatic Hormones / blood* Pancreatic Neoplasms / blood* Pancreatic Polypeptide / blood Radioimmunoassay / methods* Secretin / blood Somatostatin / blood Substance P / blood Vasoactive Intestinal Peptide / blood Zollinger-Ellison Syndrome / blood |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Gastrointestinal Hormones; 0/Pancreatic Hormones; 11061-68-0/Insulin; 1393-25-5/Secretin; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 51110-01-1/Somatostatin; 52906-92-0/Motilin; 59392-49-3/Gastric Inhibitory Polypeptide; 59763-91-6/Pancreatic Polypeptide; 62340-29-8/Glucagon-Like Peptides; 9007-92-5/Glucagon; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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