| Radioimmunoassay of the attack complex of complement in serum from patients with systemic lupus erythematosus. | |
| | |
MedLine Citation:
|
PMID: 4000197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We developed a radioimmunoassay to measure the attack complex of complement (SC5b-9) in serum from patients with systemic lupus erythematosus. The radioimmunoassay used a monoclonal antibody to an antigen of C9, which is absent from native C9 but present on SC5b-9. SC5b-9 was detectable in 13 of 63 normal subjects, with a mean value of 0.5 unit (range, 0 to 4.8), and elevated in 13 of 14 patients with active lupus. Analysis of 108 samples from the patients with lupus revealed a mean value of 10.1 units (range, 0 to 35) when the disease was active and 1.0 unit (range, 0 to 433) when it was clinically stable. SC5b-9 was a more sensitive measure of disease activity than C3, C4, or CH50; its specificity was equivalent to that of C3 and C4. SC5b-9 was elevated in serum from 6 of 49 patients with other forms of glomerulonephritis. Our study documents the presence of SC5b-9 in abnormal serum and correlates its elevation with clinical disease activity in patients with active systemic lupus erythematosus. |
| | |
Authors:
|
R J Falk; A P Dalmasso; Y Kim; S Lam; A Michael |
Related Documents
:
|
10502127 - Delayed onset of systemic lupus erythematosus in patients with "full-house" nephropathy. 2758727 - Cadralazine challenge in patients with previous hydralazine-induced lupus: a 6-month st... 19483357 - Intrapulmonary hemorrhage in collagen-vascular diseases includes a spectrum of underlyi... 12100037 - Lupus-specific kidney deposits of hsp90 are associated with altered igg idiotypic inter... 12425407 - Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nos... 19490557 - Valuing condition-specific health states using simulation contact lenses. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The New England journal of medicine Volume: 312 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1985 Jun |
Date Detail:
|
Created Date: 1985-07-10 Completed Date: 1985-07-10 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1594-9 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Antibodies, Monoclonal / diagnostic use Bacterial Infections / immunology Complement C9 / immunology Complement Membrane Attack Complex Complement System Proteins / analysis* Glomerulonephritis / immunology Humans Lupus Erythematosus, Systemic / immunology* Middle Aged Radioimmunoassay |
| Grant Support | |
ID/Acronym/Agency:
|
AI-10704/AI/NIAID NIH HHS; AM-25518/AM/NIADDK NIH HHS; AM-26149/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Complement C9; 0/Complement Membrane Attack Complex; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of prognosis on decisions regarding the care of newborns with myelodysplasia.
Next Document: Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major.