Document Detail

Radioimmunoassay of alpha-fetoprotein in children with primary intracranial tumors.
MedLine Citation:
PMID:  89937     Owner:  NLM     Status:  MEDLINE    
Serum alpha-fetoprotein (AFP) was measured in 10 cases of primary brain tumors in children (4 cases of medulloblastoma, 4 cases of germ cell tumor and 2 cases of astrocytoma). As a result, elevation in AFP was observed only in a case of embryonal carcinoma that showed partial mixture of germinoma. The absence of AFP elevation in 3 other cases of pure germinoma (atypical teratoma; pinealoma) agrees with reports which describe that, in the germ cell tumor of the gonads, a rise in AFP is not observed in pure seminoma but is found in embryonal carcinoma and endodermal sinus tumor (yolk sac tumor). The fluctuations in AFP in serum and cerebrospinal fluid are considered to be of significance in the diagnosis and treatment of primary intracranial malignant germ cell tumors.
Y Shinomiya; S Toya; T Iwata; Y Hosoda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Child's brain     Volume:  5     ISSN:  0302-2803     ISO Abbreviation:  Childs Brain     Publication Date:  1979  
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505428     Medline TA:  Childs Brain     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  450-8     Citation Subset:  IM    
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MeSH Terms
Astrocytoma / metabolism
Brain Neoplasms / metabolism*
Child, Preschool
Medulloblastoma / metabolism
Teratoma / metabolism
alpha-Fetoproteins / metabolism*
Reg. No./Substance:

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