Document Detail


Radioimmune assay of heterologous serum gamma-globulin in patients receiving rabbit antihuman thymocyte globulin.
MedLine Citation:
PMID:  54964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A radioimmune assay (RIA) method for detecting heterologous serum rabbit gamma-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit gamma-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.
Authors:
C P Bieber; E Lydick; R B Griepp; L A David; P E Oyer; E B Stinson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Transplantation     Volume:  20     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  393-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Anti-Idiotypic / analysis
Antibody Formation
Antigens / analysis
Antigens, Heterophile / analysis*
Antilymphocyte Serum / therapeutic use*
Heart Transplantation
Hemagglutination Tests
Humans
Rabbits
Radioimmunoassay
Sheep
T-Lymphocytes / immunology*
Time Factors
Transplantation, Homologous
gamma-Globulins / analysis*
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Antigens; 0/Antigens, Heterophile; 0/Antilymphocyte Serum; 0/gamma-Globulins

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