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Radiohalogenated nonnatural amino acids as PET and SPECT tumor imaging agents.
MedLine Citation:
PMID:  21793016     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Radiohalogenated α-amino acids are a diverse and useful class tumor imaging agents suitable for positron emission tomography and single photon emission computed tomography. These tracers target the increased rates of amino acid transport exhibited by many tumor cells. The most established clinical use for radiolabeled amino acids is imaging primary and recurrent gliomas, and there is growing evidence that they may also be useful for other oncologic applications, including neuroendocrine tumors and prostate cancer. This review focuses on the synthesis, radiolabeling, and preclinical evaluation of three series of nonnatural radiohalogenated amino acids: alicyclic, α,α-dialkyl, and 1H-[1,2,3]triazole amino acids which target system L, system A, and cationic amino acid transport systems, respectively.  © 2011 Wiley Periodicals, Inc. Med Res Rev.
Authors:
Jonathan McConathy; Weiping Yu; Nachwa Jarkas; Wonewoo Seo; David M Schuster; Mark M Goodman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-26
Journal Detail:
Title:  Medicinal research reviews     Volume:  -     ISSN:  1098-1128     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8103150     Medline TA:  Med Res Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
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