Document Detail

Radioguided occult lesion localization (ROLL) and excision of breast lesions using technetium-99m-macroaggregate albumin and air injection control.
MedLine Citation:
PMID:  17987790     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess the efficiency of the radioguided localization and excision technique using radiopharmaceuticals injected directly or close to occult breast lesions. We studied thirty-two consecutive patients with thirty-six occult breast lesions detected mammographically or ultrasonically categorized as BI-RADS 3, 4 or 5. Macroaggregate Albumin (MAA) labeled with (99m)Tc was administered directly or close to the lesion, guided by mammography or ultrasound, followed by an air injection for radiological control. The excision biopsy was carried out with the aid of a hand-held gamma detecting probe and the entire removal of the lesion was verified by X-ray of the surgical specimens or by intraoperatory frozen section examination. Breast cancer was found in 8.3% of BI-RADS 3 lesions, in 33.3% of the BI-RADS 4 lesions and in 66.6% of the BI-RADS 5 lesions. The radiotracer was correctly positioned in 97.2% of the specimens (35/36) allowing the removal of 97.2%. Xray confirmed the entire removal in 27 lesions (75%), intraoperatory frozen section study in 19.4% (7/36) and by both methods in 5.5% (2/36). Radioguided surgery turned out to be an important tool in the removal of non-palpable breast lesions, as a simple, fast and feasible method that can be implemented in the clinical routine of patients with non-palpable breast lesions.
R H S Machado; A C Oliveira; A C P Rocha; M C P Landesmann; F P P Martins; S A S Lopes; B Gutfilen; L M Barbosa da Fonseca
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  26     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-11-08     Completed Date:  2007-12-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  323-7     Citation Subset:  IM    
Departamento de Radiologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil.
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MeSH Terms
Breast Neoplasms / radionuclide imaging*,  surgery*
Mastectomy, Radical
Middle Aged
Radiopharmaceuticals / diagnostic use*
Technetium Tc 99m Aggregated Albumin / diagnostic use*
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Technetium Tc 99m Aggregated Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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