Document Detail


Radiographic severity in ankylosing spondylitis is associated with polymorphism in large multifunctional peptidase 2 (LMP2) in the SPARCC cohort.
MedLine Citation:
PMID:  22034108     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: There is limited data on genetic predictors of radiographic progression. We studied polymorphisms in genes involved in antigen presentation and their effect on radiographic severity and progression. METHODS: Caucasian AS patients (modified New York criteria), from two Canadian centers were enrolled. Patients in the progression study had at least two sets of x-rays at a minimum gap of 1.5 years with mSASSS scores. Peripheral blood DNA was used for genotyping a panel of 13 coding-region SNPs in the ERAP1, LMP2;, LMP7, TAP2 and TAP7 genes. Linear regression analysis was done to identify the predictors of baseline mSASSS and logistic regression for predictors of progression. Progressors were defined as patients with an increase of 1 mSASSS unit per year. RESULTS: A total of 241 AS patients (81% males and 82% HLA B27-positive) were enrolled from the two centers for predictors of baseline radiographic severity. In univariate analysis baseline mSASSS scores were associated with gender, age and the SNPs rs30187 (ERAP1) and rs17587 (LMP2). In multivariate analysis duration of disease (B=0.74; p = 1 x 10(-11) ), gender (B = 12.1; p= 5x10(-5) ) and the LMP2 SNP rs17587 (B=6.2; p=0.01) were significantly associated with baseline mSASSS. In multivariate analysis of progression, only the baseline mSASSS was a significant predictor (B=0.03; p=0.003). CONCLUSION: This is the first study to demonstrate that LMP2 variants can affect radiographic severity in AS. Baseline mSASSS remains the strongest predictor of radiographic progression but explains only a fraction of the variability seen. © 2011 American College of Rheumatology.
Authors:
N Haroon; Wp Maksymowych; P Rahman; Fwl Tsui; Fd O'Shea; Rd Inman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-27
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Affiliation:
Toronto Western Hospital and University of Toronto, Toronto, Ontario.
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