Document Detail


Radiographic results of callus distraction aided by pulsed low-intensity ultrasound.
MedLine Citation:
PMID:  11514767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine whether pulsed low-intensity ultrasound (frequency of 1.5 megahertz, pulsed by one kilohertz, signal burst width of 200 microseconds, intensity of thirty milliwatts per square centimeter, and daily treatment time of twenty minutes per day) stimulates regenerate maturation after callus distraction. DESIGN: Prospective, controlled animal trial. METHODS: Operatively, we created a fifteen-millimeter defect in the right metatarsus of eighteen female mature merino sheep. A segmental transport was begun on Day 5 using a high-stiffness experimental ring fixator. The distraction rate was one millimeter per day divided into two increments of 0.5 millimeters each. On Day 21 after the operation, distraction was finished and the maturation period started and lasted until Day 84 after operation. During this period, Group 1 was treated with a daily twenty-minute low-intensity ultrasound stimulation (frequency of 1.5 megahertz, pulsed by one kilohertz, signal burst width of 200 microseconds, intensity of thirty milliwatts per square centimeter). Group 2 had no stimulation. Animals bore full weight. Plain radiographs in the anteroposterior view were taken every two weeks during the maturation period. After the animals were killed on Day 84, anteroposterior and lateral high resolution radiographs and computed tomography (CT) scans of the regenerate were performed. For each plain and high resolution radiograph, two different relationships (callus relation, the ratio of the amount of periosteal callus to the size of the space between the proximal fragment and transported segment; and interzone relation, the ratio of the fibrous callus interzone to the size of the new formed callus) were calculated. Using CT scan, callus area, bone density, and bone mineral content were evaluated. RESULTS: The results of interzone relation (both views) and callus relation (lateral view) in high-resolution radiographs and bone mineral content in CT indicate a significantly accelerated maturation of the regenerate in the ultrasound stimulated group even when a Bonferroni-Holm adjustment was used for multiple testing. CONCLUSION: Pulsed low-intensity ultrasound appears to stimulate the healing processes in the regenerate in this animal model and may have applicability in clinical practice.
Authors:
E Mayr; A Laule; G Suger; A Rüter; L Claes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of orthopaedic trauma     Volume:  15     ISSN:  0890-5339     ISO Abbreviation:  J Orthop Trauma     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807705     Medline TA:  J Orthop Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-14     Citation Subset:  IM    
Affiliation:
Klinik für Unfall-und Wiederherstellungschirurgie, Augsburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bony Callus / physiology,  radiography*
Disease Models, Animal
External Fixators
Female
Fracture Fixation / instrumentation*,  methods
Fracture Healing / physiology
Fractures, Bone / radiography*,  therapy*
Metatarsus / injuries*
Prospective Studies
Reference Values
Sheep
Statistics, Nonparametric
Tomography, X-Ray Computed
Ultrasonic Therapy / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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