| Radiographic predictors of neurocognitive functioning in pediatric Sickle Cell disease. | |
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MedLine Citation:
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PMID: 16551451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared magnetic resonance imaging (MRI), magnetic resonance angiography, and transcranial Doppler ultrasonography as predictors of specific neurocognitive functions in children with sickle cell disease. Participants were 27 children with sickle cell anemia (hemoglobin SS) who were participants in the Stroke Prevention Trial in Sickle Cell Anemia (STOP) and had no documented history of stroke. Children's MRIs were classified as normal or silent infarct, and their magnetic resonance angiograms were classified as normal or abnormal. The highest time-averaged mean flow velocity on transcranial Doppler ultrasonographic examination of the major cerebral arteries was analyzed. Age and hematocrit also were analyzed as predictor variables. The battery of neurocognitive tests included measures of intellectual functioning, academic achievement, attention, memory, visual-motor integration, and executive functions. MRI, magnetic resonance angiography, transcranial Doppler ultrasonography, age, and hematocrit were analyzed as predictors of participants' performance on the various measures of neurocognitive functioning. Age and hematocrit were robust predictors of a number of global and specific neurocognitive functions. When age and hematocrit were controlled, transcranial Doppler ultrasonography was a significantly unique predictor of verbal memory. We found an association between low hemoglobin and neurocognitive impairment. We also found that abnormalities on transcranial Doppler ultrasonography can herald subtle neurocognitive deficits. (J Child Neurol 2006;21:37-44). |
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Authors:
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Mary C Kral; Ronald T Brown; Mark Connelly; Joel K Curé; Nada Besenski; Sherron M Jackson; Miguel R Abboud |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of child neurology Volume: 21 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-03-22 Completed Date: 2006-08-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Medical University of South Carolina, Charleston, 29425, USA. kralm@musc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anemia, Sickle Cell / complications*, psychology Attention Brain / pathology, radiography Child Cognition Disorders / complications*, diagnosis*, psychology Educational Status Female Humans Intelligence Tests Magnetic Resonance Angiography Magnetic Resonance Imaging Male Memory Neuropsychological Tests Predictive Value of Tests Psychomotor Performance Ultrasonography, Doppler, Transcranial |
| Grant Support | |
ID/Acronym/Agency:
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F31 NS43181-01/NS/NINDS NIH HHS; U10 HL 52016/HL/NHLBI NIH HHS; U10 HL 52193/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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