| Radiographic distribution of Pneumocystis carinii pneumonia in patients with AIDS treated with prophylactic inhaled pentamidine. | |
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MedLine Citation:
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PMID: 2343119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The radiographic distribution of Pneumocystis carinii pneumonia was studied in 64 consecutive patients with acquired immunodeficiency syndrome to determine the demographic and clinical factors that might be associated with predominance of the disease in the upper zones of the lungs. Twenty-three patients were receiving monthly prophylaxis with 300 mg of aerosolized pentamidine by means of inhalation; the other 41 were not receiving pentamidine and served as a control group. Parenchymal abnormalities were present in 63 of 64 patients. Pleural effusion and cystic lung lesions were uncommon and did not differ between the two groups. Patients receiving aerosolized pentamidine were more likely than control patients to have disease isolated or predominant in the upper lobes (odds ratio = 3.9, confidence interval = 1.1-14.1). After the possible effects of confounding variables were taken into account, prophylaxis remained a significant risk factor. Age and a previous history of P carinii pneumonia were not significant cofactors. The pattern of deposition or retention of the aerosolized pentamidine could be responsible for the finding of predominant P carinii pneumonia in the upper lobes of the lungs. |
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Authors:
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M H Chaffey; J S Klein; G Gamsu; P Blanc; J A Golden |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiology Volume: 175 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-06-26 Completed Date: 1990-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 715-9 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Radiology, University of California, San Francisco, School of Medicine 94143. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Administration, Inhalation Adult Aged Female Humans Lung / radiography Male Middle Aged Pentamidine / administration & dosage*, therapeutic use Pneumonia, Pneumocystis / complications, prevention & control, radiography* |
| Chemical | |
Reg. No./Substance:
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100-33-4/Pentamidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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