Document Detail


Radiographic assessment of segmental motion at the atlantoaxial junction in the Klippel-Feil patient.
MedLine Citation:
PMID:  16418636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY DESIGN: A retrospective review of 33 consecutive Klippel-Feil syndrome (KFS) patients at a single institution. OBJECTIVES: To assess in KFS patients the presence and degree of radiographic segmental motion at the atlantoaxial junction, factors contributing to such motion, and associated clinical manifestations. SUMMARY OF BACKGROUND DATA: Studies suggest that abnormal segmentation in KFS patients may result in cervical hypermobility, increasing the risk of developing neurologic compromise and the need for surgical intervention. The use of the anterior and posterior atlantodens interval (AADI/PADI) has gained interest as a method for assessing atlantoaxial instability and for space available for the cord. Although helpful for identifying instability after trauma, these measurements are not understood in KFS patients. In addition, the effects of the fusion process associated with KFS on atlantoaxial motion and associated clinical findings have not been properly addressed. METHODS: Radiographs were analyzed for the presence of occipitalization, number/location of congenitally fused segments, and the AADI and PADI. RESULTS: There were 15 males and 18 females (mean age, 13.9 years). Occipitalization occurred in 48.5% of patients. A fused C2-C3 segment was noted in 72.7% of cases. More motion with respect to AADI was evident on O-C1 and C2-C3 fusion only patients, which were all asymptomatic. Overall, 24.2% of patients were symptomatic. Mean AADI and PADI difference was 2.0 mm (symptomatic: mean, 1.5 mm; asymptomatic: mean, 2.1 mm) and -1.7 mm (symptomatic: mean, -1.0 mm; asymptomatic: mean, -2.0 mm), respectively (P > 0.05). CONCLUSIONS: Hypermobility of the atlantoaxial junction, as indicated by increased AADI on flexion-extension radiographs, is not necessarily associated with an increased risk for the development of symptoms or neurologic signs in the KFS patient. Occipitalization plays an integral role in the degree of motion at the atlantoaxial region. Greatest AADI values were in patients with occipitalization and a fused C2-C3 segment. The presence of symptoms was not related to the degree of AADI change. Evaluation of the PADI provides additional information for identifying patients at risk for developing symptoms. Nonetheless, KFS patients remain largely asymptomatic.
Authors:
Francis H Shen; Dino Samartzis; Jean Herman; John P Lubicky
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Spine     Volume:  31     ISSN:  1528-1159     ISO Abbreviation:  Spine     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-18     Completed Date:  2006-06-12     Revised Date:  2009-07-09    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-7     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA 22908-0159, USA. FHS2G@hscmail.mcc.virginia.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Atlanto-Axial Joint / physiology,  radiography*
Cervical Vertebrae / physiology,  radiography
Child
Child, Preschool
Female
Humans
Klippel-Feil Syndrome / physiopathology,  radiography*
Male
Range of Motion, Articular / physiology*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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