Document Detail

Radiofrequency ablation of liver adjacent to body of gallbladder: histopathologic changes of gallbladder wall in a pig model.
MedLine Citation:
PMID:  18212228     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of our study was to evaluate the histopathologic changes of gallbladder wall surrounding radiofrequency ablation zones in pig livers and to assess the risk factors for thermal injury of gallbladder wall in terms of distance of the electrode, electrode direction in relation to the gallbladder wall, and time of sacrifice of the animal. MATERIALS AND METHODS: The study was performed in 15 pigs using an internally cooled single electrode with a 1-cm electrically active tip under sonographic guidance. Twenty-three hepatic ablation zones abutting the gallbladder were analyzed in three phases on the basis of the distance of the electrode (group A, 0.5 cm; group B, 1.0 cm), electrode direction (perpendicular or parallel), and time of sacrifice (immediate or delayed [7 days after radiofrequency ablation]). We evaluated the gross changes, the depth of thermal injury, and the grade of abnormal microscopic changes in the gallbladder wall. Data analysis was performed on the basis of the Fisher's exact test. RESULTS: Discoloration and perforation were more frequent in group A (60%, 6/10, and 20%, 2/10, respectively) than in group B (25%, 2/8, and 0%, respectively, p > 0.05). Perforation was more frequent in the parallel direction and delayed phase (33.3%, 1/3, and 40%, 2/5, respectively) compared with the perpendicular direction and immediate phase (14.3%, 1/7, and 0%, respectively, p > 0.05). Depth of thermal injury showed a significant difference between group A and group B for full-thickness involvement (53.8%, 7/13, versus 0%, respectively, p < 0.05). Abnormal microscopic changes showed that parallel direction and immediate phase were more frequent with full-thickness involvement (71.4%, 5/7, and 71.4%, 5/7, respectively) compared with perpendicular direction and delayed phase (33.3%, 2/6, and 33.3%, 2/6, respectively, p > 0.05). CONCLUSION: Hepatic radiofrequency ablation abutting the gallbladder can produce substantial thermal injury of the gallbladder wall, including perforation, especially when performed without a safe distance.
Jiwon Lee; Hyunchul Rhim; Yong Hwan Jeon; Hyo K Lim; Won Jae Lee; Dongil Choi; Young-Sun Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  190     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-23     Completed Date:  2008-02-11     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-25     Citation Subset:  AIM; IM    
Department of Radiology, Kangwon National University College of Medicine, Kangwon-do, South Korea.
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MeSH Terms
Catheter Ablation / adverse effects*,  methods
Disease Models, Animal*
Gallbladder / injuries*,  pathology*
Hepatectomy / adverse effects*,  methods

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