| Radiofrequency ablation for hepatocellular carcinoma: use of low vs maximal radiofrequency power. | |
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MedLine Citation:
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PMID: 21427178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate whether radiofrequency (RF) ablation with low power (LP) or maximal power (MP) for hepatocellular carcinoma (HCC) can achieve optimal ablation and fewer adverse effects. METHODS: RF ablation was performed with MP in 101 patients (129 tumours) and with LP in 46 patients (61 tumours). MP RF ablation used power of >120 W. RF power below this was designated as LP. Clinical outcomes were also analysed in subgroups of high-risk tumours near the bile duct and blood vessels. RESULTS: Primary effectiveness was achieved in 91.8% in the LP group and 89.9% in the MP group (p = 0.795). 1 and 2-year local tumour progression rates were 28% and 30%, respectively, in the LP group, and 24% and 29%, respectively, in the MP group (p = 0.70). 1 and 2-year survival rates were 98% and 98%, respectively, in the LP group, and 93% and 90%, respectively, in the MP group (p = 0.216). The MP group had more adverse effects, with post-RF ablation syndrome, asymptomatic pleural effusion and ascites, than the LP group (20% vs 39% in the MP group; p = 0.027); however, there was no significant difference in major complication rates (6% in the MP and LP groups; p = 0.497). Among the patients with high-risk tumours, RF ablation using MP vs LP was comparable in primary effectiveness (91.7% vs 95.2%; p = 0.618), local tumour progression (42.9% vs 29.2%; p = 0.304) and overall complications (5% vs 8%; p=0.618). CONCLUSION: RF ablation with LP and MP are comparable in clinical outcomes but considerably fewer adverse effects were encountered in the LP group. |
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Authors:
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T C Macatula; C-C Lin; C-J Lin; W-T Chen; S-M Lin |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2011-03-22 |
Journal Detail:
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Title: The British journal of radiology Volume: 85 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-05 Completed Date: 2012-08-06 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: e102-9 Citation Subset: AIM; IM |
Affiliation:
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Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Hepatocellular / surgery* Catheter Ablation / methods* Female Humans Liver Neoplasms / surgery* Male Middle Aged Retrospective Studies |
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