| Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention. | |
| | |
MedLine Citation:
|
PMID: 17599667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Idiopathic premature ventricular complexes (PVCs) usually are considered benign, even when frequent. However, case reports have demonstrated a possible link between frequent PVCs and left ventricular (LV) dysfunction. In addition, frequent PVCs recently were demonstrated to be associated with increased LV dimensions and cardiomyopathy. METHODS: Among 60 consecutive patients with idiopathic, frequent PVCs (>10/hour), a reduced LV ejection fraction (EF; mean 34% +/- 13%) was present in 22 (37%) patients. Patients with decreased LV function had a greater PVC burden on a 24-hour Holter monitor than patients with normal EF (37% +/- 13% vs. 11% +/- 10% of all QRS complexes; P <.0001). There was a significant inverse correlation between the PVC burden and the EF before ablation (r = 0.73, P <.0001). RESULTS: The PVCs originated in the right ventricular outflow tract in 31 (52%) of 60 patients, the LV outflow tract in 9 (15%) of 60 patients, and in other sites in 13 (22%) of 60 patients. The site of PVC origin could not be determined in seven patients. Ablation was completely successful in 48 (80%) patients. In patients with an abnormal EF before ablation, LV function normalized in 18 (82%) of 22 patients from a baseline of 34% to 59% +/- 7% (P <.0001) within 6 months. In the four patients in whom ablation was ineffective, the EF further declined from 34% +/- 10% to 25% +/- 7% (P = .06) during follow-up. In a control group of 11 patients with a similar PVC burden (30% +/- 8%) and a reduced EF (28% +/- 13%) who did not undergo ablation, the EF remained unchanged in 10/11 patients over 19 +/- 17 months of follow-up and one patient underwent heart transplantation. CONCLUSION: LV dysfunction in the setting of frequent, idiopathic PVCs may represent a form of cardiomyopathy that can be reversed by catheter ablation of the PVCs. |
| | |
Authors:
|
Frank Bogun; Thomas Crawford; Stephen Reich; Todd M Koelling; William Armstrong; Eric Good; Krit Jongnarangsin; Joseph E Marine; Aman Chugh; Frank Pelosi; Hakan Oral; Fred Morady |
Related Documents
:
|
3566577 - Clinical experience with bypass of the left ventricle using a roller pump. 16084337 - High prevalence of important cardiac findings in patients with peripheral arterial dise... 12442927 - Doppler indices of diastolic transmitral flow velocity are invalid indicators of myocar... 17134637 - Left ventricular geometry and mortality in patients >70 years of age with normal ejecti... 4043887 - Monarticular nontraumatic synovitis of the metatarsophalangeal joint: a new diagnosis? 9224527 - Concomitant deficiency of beta- and gamma-sarcoglycans in 20 alpha-sarcoglycan (adhalin... |
Publication Detail:
|
Type: Journal Article Date: 2007-03-12 |
Journal Detail:
|
Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 4 ISSN: 1547-5271 ISO Abbreviation: Heart Rhythm Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-06-29 Completed Date: 2007-08-02 Revised Date: 2009-10-27 |
Medline Journal Info:
|
Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
|
Languages: eng Pagination: 863-7 Citation Subset: IM |
Affiliation:
|
University of Michigan Medical Center, Ann Arbor, MI 48109, USA. fbogun@umich.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Catheter Ablation / methods* Female Humans Male Middle Aged Retrospective Studies Ventricular Function, Left / physiology Ventricular Premature Complexes / therapy* |
| Comments/Corrections | |
Comment In:
|
Heart Rhythm. 2007 Jul;4(7):868-9
[PMID:
17599668
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Amicrobial pustulosis associated with IgA nephropathy and Sjögren's syndrome.
Next Document: Increased expression of adenosine A2A receptors in patients with spontaneous and head-up-tilt-induce...