Document Detail

Radiofrequency Ablation versus Cryosurgery Ablation for Hepatocellular Carcinoma: A Meta-Analysis.
MedLine Citation:
PMID:  23321123     Owner:  NLM     Status:  Publisher    
Background/Aims: To investigate the meta-analysis of the effect between radiofrequency ablation (RFA) and cryosurgery ablation (CSA) in treating unresectable hepatocellular carcinoma (HCC). Methodology: Systematic literature search of relevant clinical studies was carried out in Pubmed, Embase, Google Scholar, the Cochrane Library Central databases and the Chinese National Knowledge Infrastructure databases. Data were ed independently by two reviewers. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated. Results: Primary outcomes were the mortality, complication and local recurrence. Three prospective study and one retrospective studies were finally eligible for meta-analysis, involving a total of 433 HCC patients (180 with RFA and 253 with CSA). RFA was significantly superior to CSA in complication (OR: 2.80, 95% CI: 1.54-5.09); local recurrence of patient (OR: 4.02, 95% CI: 1.93-8.39); local recurrence of tumor (OR: 1.96, 95% CI: 1.12-3.42). No significant difference was found in mortality (OR: 2.21, 95% CI: 0.45-10.8) between RFA and CSF. Conclusions: Although multiple confounders exist in the clinical trials especially the bias in patient selection, RFA was significantly superior to CSA in the treatment of HCC.
Yao-Zhen Huang; Shi-Chun Zhou; Hongyu Zhou; Mingwei Tong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  60     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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