| Radiofrequency ablation of the liver: extended effect of transcatheter arterial embolization with iodized oil and gelatin sponge on histopathologic changes during follow-up in a pig model. | |
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MedLine Citation:
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PMID: 20884228 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To assess the extended effects of transcatheter arterial embolization with iodized oil and gelatin sponge on liver histopathologic changes in radiofrequency (RF)-ablated zones and the surrounding liver parenchyma in a pig model. MATERIALS AND METHODS: Eighteen consecutive pigs subjected to 36 RF applications performed immediately after segmental embolization with iodized oil and gelatin sponge to the left lobe of the liver (embolization/RF ablation) were euthanized immediately after the procedure or 1 or 4 weeks later. The right lobes were used as controls for RF applications without embolization. The ablated zones and the surrounding liver parenchyma were measured and examined histopathologically. RESULTS: The average maximum ablated zone was significantly larger in the embolization/RF ablation specimens than in the RF ablation-alone specimens at all three follow-up time points. Ten of the 12 specimens obtained immediately after embolization/RF ablation showed wide hemorrhagic areas spreading to the periphery of the liver and microscopically showed marked intralobular congestion with sinusoidal dilation. This hemorrhagic change had disappeared in all the specimens obtained 1 week after embolization/RF ablation, but 10 of the 12 specimens showed wedge-shaped areas of segmental degenerative parenchyma beginning at the ablated zone and extending to the periphery of the liver; these were microscopically revealed to be areas of coagulative necrosis, indicating hepatic infarction. The sizes of these necrotic zones had decreased at 4 weeks after embolization/RF ablation. CONCLUSIONS: RF ablation performed immediately after embolization in normal pig liver induced large ablated zones accompanied by wedge-shaped areas of segmental infarction. |
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Authors:
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Manabu Morimoto; Kazushi Numata; Akinori Nozawa; Masaaki Kondo; Akito Nozaki; Masayuki Nakano; Katsuaki Tanaka |
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Publication Detail:
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Type: Journal Article Date: 2010-09-29 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 21 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1716-24 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Gastroenterological Center, Yokohama City University Medical Center, Minami-ku, Yokohama, Japan. morimoto@urahp.yokohama-cu.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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