Document Detail


Radioembolization with yttrium-90 microspheres for pancreatic cancer liver metastases: results from a pilot study.
MedLine Citation:
PMID:  21388058     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Patients with liver metastases from pancreatic adenocarcinomas have a dismal prognosis. Surgical resection remains the only curative option but is appropriate for only a minority of patients as a treatment option. This is the first study to examine the safety and efficacy of radioembolization with yttirum-90 microspheres for these patients.
PATIENTS AND METHODS: All patients with histologically proven pancreatic carcinoma liver metastases referred to a single institution from 2006-2009 were included in the study. After radioembolization, follow-up abdominal computed tomography scans were performed to assess response according to the Response Criteria in Solid Tumors guidelines.
RESULTS: Seven patients were identified from our prospectively collected data base. Of the five patients with available computed tomography follow-up, 2 patients achieved a partial response and 1 patient had stable disease. One patient with partial response survived for nearly 15 months after radioembolization therapy. No patient experienced major post-radioembolization complications.
CONCLUSIONS: Radioembolization with yttrium-90 microspheres may have a useful role in treating patients with pancreatic carcinoma liver metastases in a multimodality setting. Results of the current study warrant further investigation of this novel treatment.
Authors:
Christopher Cao; Tristan D Yan; David L Morris; Lourens Bester
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumori     Volume:  96     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2011-03-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  955-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of New South Wales, St. George Hospital, Australia.
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