| Radiochemical synthesis of etomoxir. | |
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MedLine Citation:
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PMID: 21036624 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Sodium 2-{6-(4-chlorophenoxy)hexyl}oxirane-2-carboxylate (Etomoxir) inhibits transport of fatty acids via the carnitine shuttle into mitochondria of muscle cells and prevents long chain fatty acids from providing energy through β-oxidation especially for muscle contraction. The objective of this synthesis is to develop a method for radioiodination of Etomoxir in order to explore its potential in diagnostic metabolic studies and molecular imaging. Thus, a method is described for the radiochemical synthesis and purification of ethyl 2-{6-(4-[(131)I]iodophenoxy)hexyl}oxirane-2-carboxylate (3) and 2-{6-(4-[(131)I]iodo-phenoxy)hexyl}oxirane-2-carboxylic acid (4). For the synthesis of these new agents, ethyl 2-{6-(4-bromophenoxy)hexyl}oxirane-2-carboxylate (1) and 2-{6-(4-bromophenoxy)hexyl}oxirane-2-carboxylic acid (2) were refluxed with [(131)I]NaI in the presence of anhydrous acetone at a temperature of 80°C and 90°C for a period of 3-4 hours, respectively. The method of radiolabeling, based on the nucleophilic exchange reaction, resulted in a radiochemical yield of 43% and 67% for compounds 3 and 4, respectively. This paper reports on the labeling of etomoxir with radioiodine as (124)I labeled etomoxir may be of great importance in molecular imaging. |
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Authors:
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Hafiz G Abbas; M Yunus; Ludwig E Feinendegen |
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Publication Detail:
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Type: Journal Article Date: 2010-10-19 |
Journal Detail:
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Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Volume: 69 ISSN: 1872-9800 ISO Abbreviation: Appl Radiat Isot Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306253 Medline TA: Appl Radiat Isot Country: England |
Other Details:
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Languages: eng Pagination: 415-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Nuclear Medicine & Oncology, New Campus Road, Lahore, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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