| Radiobiological properties of high-energy cyclotron-produced neutrons used for radiotherapy. | |
| | |
MedLine Citation:
|
PMID: 808829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Radiobiological properties of high-energy cyclotron-produced neutrons were investigated. The survival curve for mammalian cells exposed to 35 MeV neutrons has an appreciable shoulder, but exhibits a significant initial slope at low doses. split-dose experiments, using doses comparable to the daily fractions of neutron therapy, indicate no repair of sublethal damage. The nitroimidazoles, and particularly Flagyl, have been shown to selectively sensitize hypoxic cells to the effects of x-rays. Experiments demonstrated that Flagyl is equally effective in reducing the oxygen enhancement ratio for high-energy neutrons. Hypoxic sensitizers must by regarded as an adjunct to neutron therapy, rather than as a competitor. |
| | |
Authors:
|
E J Hall; L Roizin-Towie; R B Theus; L S August |
Related Documents
:
|
11099209 - Predictions of a stochastic model of bone marrow cell survival in high dose rate radiat... 1106959 - An historical survey of radiobiology and radiotherapy with fast neutrons. 22057229 - Tissue concentrations of pesticides, pcbs and metals among ospreys, pandion haliaetus, ... 16030059 - Forbush decrease effects on radiation dose received on-board aeroplanes. 12956189 - Variations in skin dose using 6mv or 18mv x-ray beams. 19872349 - A theoretical consideration of the action of x-rays on the protozoan colpidium colpoda. 8870039 - Combined pcpa and muscarinic antagonist treatment produces a deficit in rat water maze ... 6653669 - Hyponeophagia in the roman rat strains: effects of 5-methoxy-n,n-dimethyltryptamine, di... 9517769 - Induction of remission in wegener's granulomatosis with low dose methotrexate. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Radiology Volume: 117 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1975 Oct |
Date Detail:
|
Created Date: 1975-11-22 Completed Date: 1975-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 173-8 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Survival / radiation effects* Cells, Cultured Cricetinae Fast Neutrons Gamma Rays Radiation Dosage Radiation Effects* Radiotherapy Dosage Radiotherapy, High-Energy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bladder cancer: results of radiation therapy in 384 patients.
Next Document: Acute and late effects of 16- and 50-MeVd leads to Be neutrons on the oral mucosa of rhesus monkeys.