Document Detail

Radiobiological properties of high-energy cyclotron-produced neutrons used for radiotherapy.
MedLine Citation:
PMID:  808829     Owner:  NLM     Status:  MEDLINE    
Radiobiological properties of high-energy cyclotron-produced neutrons were investigated. The survival curve for mammalian cells exposed to 35 MeV neutrons has an appreciable shoulder, but exhibits a significant initial slope at low doses. split-dose experiments, using doses comparable to the daily fractions of neutron therapy, indicate no repair of sublethal damage. The nitroimidazoles, and particularly Flagyl, have been shown to selectively sensitize hypoxic cells to the effects of x-rays. Experiments demonstrated that Flagyl is equally effective in reducing the oxygen enhancement ratio for high-energy neutrons. Hypoxic sensitizers must by regarded as an adjunct to neutron therapy, rather than as a competitor.
E J Hall; L Roizin-Towie; R B Theus; L S August
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  117     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Survival / radiation effects*
Cells, Cultured
Fast Neutrons
Gamma Rays
Radiation Dosage
Radiation Effects*
Radiotherapy Dosage
Radiotherapy, High-Energy*

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