Document Detail


Radiobiological properties of high-energy cyclotron-produced neutrons used for radiotherapy.
MedLine Citation:
PMID:  808829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Radiobiological properties of high-energy cyclotron-produced neutrons were investigated. The survival curve for mammalian cells exposed to 35 MeV neutrons has an appreciable shoulder, but exhibits a significant initial slope at low doses. split-dose experiments, using doses comparable to the daily fractions of neutron therapy, indicate no repair of sublethal damage. The nitroimidazoles, and particularly Flagyl, have been shown to selectively sensitize hypoxic cells to the effects of x-rays. Experiments demonstrated that Flagyl is equally effective in reducing the oxygen enhancement ratio for high-energy neutrons. Hypoxic sensitizers must by regarded as an adjunct to neutron therapy, rather than as a competitor.
Authors:
E J Hall; L Roizin-Towie; R B Theus; L S August
Related Documents :
11099209 - Predictions of a stochastic model of bone marrow cell survival in high dose rate radiat...
1106959 - An historical survey of radiobiology and radiotherapy with fast neutrons.
22057229 - Tissue concentrations of pesticides, pcbs and metals among ospreys, pandion haliaetus, ...
16030059 - Forbush decrease effects on radiation dose received on-board aeroplanes.
12956189 - Variations in skin dose using 6mv or 18mv x-ray beams.
19872349 - A theoretical consideration of the action of x-rays on the protozoan colpidium colpoda.
8870039 - Combined pcpa and muscarinic antagonist treatment produces a deficit in rat water maze ...
24351409 - Dose uncertainties in impt for oropharyngeal cancer in the presence of anatomical, rang...
6653669 - Hyponeophagia in the roman rat strains: effects of 5-methoxy-n,n-dimethyltryptamine, di...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  117     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Survival / radiation effects*
Cells, Cultured
Cricetinae
Fast Neutrons
Gamma Rays
Radiation Dosage
Radiation Effects*
Radiotherapy Dosage
Radiotherapy, High-Energy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bladder cancer: results of radiation therapy in 384 patients.
Next Document:  Acute and late effects of 16- and 50-MeVd leads to Be neutrons on the oral mucosa of rhesus monkeys.