Document Detail


Radiobiological effect of heparin in Swiss mice, human amnion cells and E. coli B/r irradiated with Co60 gamma-rays.
MedLine Citation:
PMID:  6364199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The radiobiological action of Heparin was investigated using the test systems E. Coli B/r, Human Amnion (HA) cells and Swiss mice. The Heparin treatment of these systems effected following changes in their response towards irradiation with Co60 gamma-rays: (a) more sensitization of E. coli B/r in hypoxic than in oxic condition, (b) no significant modification for HA cells in oxic condition but their sensitization under hypoxia, (c) larger recovery of anodic electrophoretic mobility of irradiated HA cells, (d) increased life span and smaller reduction in the splenic and thymus weights of irradiated Swiss mice. It seems, therefore, that Heparin, a natural molecule of animal world, possesses the potentiality to modify radiation response of living systems and may find useful application in radiation therapy.
Authors:
K A Chaubal; C S Godbole
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  22     ISSN:  0301-634X     ISO Abbreviation:  Radiat Environ Biophys     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-06     Completed Date:  1984-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  281-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amnion / drug effects,  radiation effects*
Animals
Anoxia / physiopathology
Cells, Cultured
Cobalt Radioisotopes / administration & dosage*
Escherichia coli / drug effects,  radiation effects*
Female
Gamma Rays
Heparin / pharmacology*
Humans
Mice
Mice, Inbred Strains
Organ Size / radiation effects
Radiation-Sensitizing Agents / pharmacology*
Spleen / radiation effects
Thymus Gland / radiation effects
Chemical
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Radiation-Sensitizing Agents; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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