Document Detail

Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response.
MedLine Citation:
PMID:  8946017     Owner:  NLM     Status:  MEDLINE    
This paper reviews the experimental results showing that a prior exposure to a low dose of ionising radiation induces an adaptive response expressed as a reduction of gene mutation in various cell systems. The data show that the mutagenic adaptation shares common features with the clastogenic adaptation, i.e., priming dose level, kinds of conditioning agents, time interval between conditioning and challenging treatments, degree of induced protective effect (40-75%), transitory response and inhibition by 3-aminobenzamide, a DNA repair inhibitor. Moreover, the deletion-type mutations are predominantly reduced in adapted cells, suggesting that the mechanism underlying mutagenic adaptation preferentially facilitates the removal of the DNA lesions leading to deletion-type mutations. These lesions are thought to be double-strand breaks which are likely to be also involved in the production of chromosomal damage. Recent findings on the molecular processes implicated in the cellular response to radiation provide some clues for the mechanisms that could be triggered by low-dose exposure and ultimately contribute to the protective effect. There is some evidence that the protein kinase C-mediated signalling pathway is a key step for the transduction of the low-dose-induced signal. Several recent reports indicate that the low-dose triggers changes in the expression of several genes whose products, though most of them are still not identified, would be related to DNA repair and/or control of cell cycle progression.
O Rigaud; E Moustacchi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mutation research     Volume:  358     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1996-12-30     Completed Date:  1996-12-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
Institut Curie-Section Recherche, URA 1292 CNRS, Paris, France.
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MeSH Terms
Adaptation, Physiological / physiology*,  radiation effects*
DNA Repair
Dose-Response Relationship, Radiation
Hypoxanthine Phosphoribosyltransferase / genetics,  radiation effects
Mutation / radiation effects*
Signal Transduction
Reg. No./Substance:
EC Phosphoribosyltransferase

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