Document Detail


Radioactive synoviorthesis in patients with hemophilia with factor inhibitor.
MedLine Citation:
PMID:  9345203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In nine patients with hemophilia and factor inhibitor (six with hemophilia A; three with hemophilia B), 19 joints were treated with radioactive synoviorthesis using Au-198. Ages ranged from 3 to 40 years. Synoviorthesis was performed when the antibody titer was low (< 10 Bethesda units), thus making hemostasis possible by factor administration for 2 to 4 days. On five occasions, radioactive synoviorthesis was performed simultaneously with tolerance induction according to the Malmö protocol. A bleeding free interval of more than 6 months was obtained in 11 joints, six of which remained bleeding free for more than a year. At long term followup (range, 18-182 months) five joints were rated good, one joint was fair, and 11 joints were poor. Although the results are inferior to those for patients with hemophilia without inhibitor, radioactive synoviorthesis should be considered because of its ease of performance and the definite decrease in joint bleeding frequency that it brings about. This is of particular interest in patients with hemophilia caused by factor inhibitor who otherwise are difficult to treat.
Authors:
T Löfqvist; C Petersson; I M Nilsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  AIM; IM    
Affiliation:
Department of Coagulation Disorders, University of Lund, University Hospital, Malmö, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies / blood
Child
Child, Preschool
Clinical Protocols
Factor IX / antagonists & inhibitors,  therapeutic use
Factor VIII / antagonists & inhibitors,  therapeutic use
Follow-Up Studies
Gold Radioisotopes / administration & dosage,  therapeutic use*
Hemarthrosis / etiology,  prevention & control
Hemophilia A / complications*,  drug therapy
Hemophilia B / complications,  drug therapy
Hemostatic Techniques
Humans
Immune Tolerance
Radiopharmaceuticals / administration & dosage,  therapeutic use*
Remission Induction
Synovitis / etiology,  radiotherapy*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antibodies; 0/Gold Radioisotopes; 0/Radiopharmaceuticals; 9001-27-8/Factor VIII; 9001-28-9/Factor IX

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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