Document Detail

Radioactive seed localization for non-palpable breast cancer.
MedLine Citation:
PMID:  23456627     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Radioactive seed localization (RSL) is an alternative to wire localization for guiding surgical excision of non-palpable breast cancer. This review provides an overview of the available evidence on the accuracy of RSL in patients undergoing breast-conserving surgery.
METHODS: PubMed, Embase and the Cochrane Library were searched systematically in January 2012 for studies that addressed localization of non-palpable breast cancer using an iodine-125-labelled seed. Studies were deemed eligible if they reported on the proportion of patients with tumour-positive margins after RSL, the proportion of patients needing re-excision after RSL, and procedural complications.
RESULTS: Six studies reported data on RSL in 1611 patients with non-palpable breast lesions. Overall complete resection rates ranged from 73 to 96.7 per cent. Three studies included over 300 patients, and complete resection rates in these studies varied between 89.5 and 96.7 per cent. The risk of seed migration and failure of seed placement ranged from 0 to 0.6 per cent and 0 to 7.2 per cent respectively.
CONCLUSION: Available scientific evidence suggests that RSL is a safe and accurate technique for localization of non-palpable breast lesions.
M W Barentsz; M A A J van den Bosch; W B Veldhuis; P J van Diest; R M Pijnappel; A J Witkamp; H M Verkooijen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of surgery     Volume:  100     ISSN:  1365-2168     ISO Abbreviation:  Br J Surg     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-04-18     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  582-8     Citation Subset:  AIM; IM    
Copyright Information:
© 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons Ltd.
Centre of Interventional Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Breast Neoplasms / radionuclide imaging*,  surgery
Epidemiologic Methods
Feasibility Studies
Iodine Radioisotopes / diagnostic use*
Middle Aged
Preoperative Care / methods
Radiopharmaceuticals / diagnostic use*
Reoperation / statistics & numerical data
Sensitivity and Specificity
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Radiopharmaceuticals
Comment In:
Br J Surg. 2013 Aug;100(9):1253-4   [PMID:  23842838 ]
Br J Surg. 2013 Aug;100(9):1253   [PMID:  23842837 ]

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