| Radioactive 133-Xenon gas-filled balloon to prevent restenosis: dosimetry, efficacy, and safety considerations. | |
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MedLine Citation:
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PMID: 12163434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ionizing radiation administered intraluminally via catheter-based systems using solid beta and gamma sources or liquid-filled balloons has shown reduction in the neointima formation after injury in the porcine model. We propose a novel system that uses a 133-Xenon (133Xe) radioactive gas-filled balloon catheter system. METHODS AND RESULTS: Overstretch balloon injury was performed in the coronary arteries of 33 domestic pigs. A novel 133Xe radioactive gas-filled balloon (3.5/45 mm) was positioned to overlap the injured segment with margins. After vacuum was obtained in the balloon catheter, approximately 2.5 cc of 133Xe gas was injected to fill the balloon. Doses of 0, 7.5, 15, and 30 Gy were delivered to a distance of 0.25 mm from the balloon surface. The dwell time ranged from 1.0 to 4.0 minutes, depending on the dose. Localization of 133Xe in the balloon was verified by a gamma camera. The average activity in a 3.5/45-mm balloon was measured at 67.7+/-12.1 mCi, and the total diffusion loss of the injected dose was 0.26% per minute of the injected dose. Bedside radiation exposure measured between 2 and 6 mR/h, and the shallow dose equivalent was calculated as 0.037 mrem per treatment. Histomorphometric analysis at 2 weeks showed inhibition of the intimal area (intimal area corrected for medial fracture length [IA/FL]) in the irradiated segments of 0.26+/-0.08 with 30 Gy, 0.07+/-0.24 with 15 Gy, and 0.12+/-0.89 with 7.5 Gy versus 0.76+/-0.08 with control P<0.001. CONCLUSIONS: 133Xe gas-filled balloon is feasible and effective in the reduction of neointima formation in the porcine model and safe for use in coronary arteries. |
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Authors:
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Marc Apple; Ron Waksman; Rosanna C Chan; Yoram Vodovotz; Jana Fournadjiev; Bill G Bass |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 106 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-06 Completed Date: 2002-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 725-9 Citation Subset: AIM; IM |
Affiliation:
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Parkview Radiation Oncology Center, Fort Wayne, Ind, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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adverse effects,
methods* Animals Brachytherapy / adverse effects, methods* Coronary Restenosis / pathology, prevention & control* Dose-Response Relationship, Radiation Gases / therapeutic use Radiation Dosage Swine Xenon Radioisotopes / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Gases; 0/Xenon Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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