| Radio-protective effect of sodium meclofenamate. A prospective clinical trial. | |
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MedLine Citation:
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PMID: 2681495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twentyfour patients treated with irradiation to either their pelvis or their chest for neoplastic disease were included in a randomized study of radioprotection with sodium meclofenamate (Meclomen) (SM). Seventeen patients received SM 100 mg, p.os, t.i.d., and seven received placebo. The long-range radiation related chronic gastrointestinal and urinary tract toxicity was diminished by SM. At 12 months post irradiation, SM treated patients experienced less gastrointestinal and urinary symptoms, as well as less measured bladder contraction, than the controls. Acute gastrointestinal signs of radiotoxicity, however, seemed to have been enhanced by SM. The treated patients suffered from nausea, vomiting, and diarrhea. These acute toxic effects were temporary and reversible. |
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Authors:
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M Mahafzah; J Halpern; H R Nava; R P Huben; S Sayyid; W Bryson; J L Ambrus |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of medicine Volume: 20 ISSN: 0025-7850 ISO Abbreviation: J Med Publication Date: 1989 |
Date Detail:
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Created Date: 1989-12-21 Completed Date: 1989-12-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505566 Medline TA: J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 261-72 Citation Subset: IM |
Affiliation:
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Department of Medicine, Sisters of Charity Hospital, Buffalo, NY 14214. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anthranilic Acids / therapeutic use* Combined Modality Therapy Digestive System / drug effects, radiation effects Double-Blind Method Humans Meclofenamic Acid / therapeutic use* Middle Aged Neoplasms / drug therapy, radiotherapy* Prospective Studies Radiation Injuries / prevention & control Radiation-Protective Agents / therapeutic use* Randomized Controlled Trials as Topic Urinary Bladder / drug effects, radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Anthranilic Acids; 0/Radiation-Protective Agents; 644-62-2/Meclofenamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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