Document Detail

Radio frequency transmyocardial revascularization enhances angiogenesis and causes myocardial denervation in canine model.
MedLine Citation:
PMID:  10918289     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Transmyocardial revascularization (TMR) relieves angina and improves exercise tolerance in patients. Angiogenesis and myocardial denervation have been proposed as factors contributing to these benefits. To test whether radio frequency transmyocardial revascularization (RF-TMR) enhances angiogenesis and causes myocardial denervation. STUDY DESIGN/MATERIALS AND METHODS: RF-TMR channels were created in 12 dogs which survived up to 4 weeks. Bromodeoxyuridine was administered subcutaneously to mark proliferating cells as an assay of angiogenesis. Western blot analysis of tyrosine hydroxylase and blood pressure response to topical bradykinin were used as indices of myocardial denervation. RESULTS: RF-TMR increased local vascularity by an average of 50%, whereas the rate of vascular cell proliferation was tripled over that of the untreated region. Changes in mean arterial pressure with bradykinin and tyrosine hydroxylase content were significantly decreased in RF-TMR regions as compared with normal myocardium in the same hearts. CONCLUSION: RF-TMR enhances angiogenesis and causes myocardial denervation in canine myocardium as with laser TMR.
N Yamamoto; A Gu; C M DeRosa; J Shimizu; D R Zwas; C R Smith; D Burkhoff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  27     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-27     Completed Date:  2000-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-28     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Department of Surgery, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Blotting, Western
Disease Models, Animal
Heart / radiation effects*
Laser Therapy*
Lasers / adverse effects
Myocardial Ischemia / complications,  therapy*
Myocardial Revascularization / methods*
Myocardium / enzymology,  pathology
Radio Waves / adverse effects,  therapeutic use*
Tyrosine 3-Monooxygenase / analysis
Reg. No./Substance:
EC 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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