| Radio frequency transmyocardial revascularization enhances angiogenesis and causes myocardial denervation in canine model. | |
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MedLine Citation:
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PMID: 10918289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Transmyocardial revascularization (TMR) relieves angina and improves exercise tolerance in patients. Angiogenesis and myocardial denervation have been proposed as factors contributing to these benefits. To test whether radio frequency transmyocardial revascularization (RF-TMR) enhances angiogenesis and causes myocardial denervation. STUDY DESIGN/MATERIALS AND METHODS: RF-TMR channels were created in 12 dogs which survived up to 4 weeks. Bromodeoxyuridine was administered subcutaneously to mark proliferating cells as an assay of angiogenesis. Western blot analysis of tyrosine hydroxylase and blood pressure response to topical bradykinin were used as indices of myocardial denervation. RESULTS: RF-TMR increased local vascularity by an average of 50%, whereas the rate of vascular cell proliferation was tripled over that of the untreated region. Changes in mean arterial pressure with bradykinin and tyrosine hydroxylase content were significantly decreased in RF-TMR regions as compared with normal myocardium in the same hearts. CONCLUSION: RF-TMR enhances angiogenesis and causes myocardial denervation in canine myocardium as with laser TMR. |
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Authors:
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N Yamamoto; A Gu; C M DeRosa; J Shimizu; D R Zwas; C R Smith; D Burkhoff |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 27 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 2000 |
Date Detail:
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Created Date: 2000-09-27 Completed Date: 2000-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 18-28 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Wiley-Liss, Inc. |
Affiliation:
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Department of Surgery, Columbia University, New York, New York 10032, USA. nori_y@med.okayama-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Disease Models, Animal Dogs Echocardiography Heart / radiation effects* Humans Laser Therapy* Lasers / adverse effects Myocardial Ischemia / complications, therapy* Myocardial Revascularization / methods* Myocardium / enzymology, pathology Radio Waves / adverse effects, therapeutic use* Tyrosine 3-Monooxygenase / analysis |
| Chemical | |
Reg. No./Substance:
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EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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