Document Detail

Radicals produced by the reactions of SO4- with uridine and its derivatives. Studies by pulse radiolysis and gamma-radiolysis.
MedLine Citation:
PMID:  2900863     Owner:  NLM     Status:  MEDLINE    
Using a pulse radiolysis technique, the sulphate radical, SO4-, has been demonstrated to react with uridine, 3'-UMP and 5'-UMP to produce intermediates of a new type, decaying according to a first-order rate law with k = 2.1, 4.1, 3.0 x 10(5) s-1 respectively at pH 7. The rate for uridine increases slightly with increasing pH. With deoxyuridine and 2', 3'-isopropylidene uridine, on the other hand, OH adduct radicals with longer lives (second-order decay) were found in accordance with the known fact that similar radicals are produced from N(1)-methylated uracils with SO4-. On gamma-irradiation of similar solutions containing the substrates that produce such short-lived species, chain reactions and high yields of unaltered uracil were found. Some optical properties are detailed and a probable structure of the short-lived species is discussed in relation to the substituent effect at the 2' position of the sugar part and to its strong reducing ability revealed by the rapid reaction with TNM.
S Fujita; Y Nagata; T Dohmaru
Related Documents :
19764763 - Studies on the mechanism, selectivity, and synthetic utility of lactone reduction using...
3000813 - Biliverdin as an electron transfer catalyst for superoxide ion in aqueous medium.
20422673 - Renewable h2 from glycerol steam reforming: effect of la2o3 and ceo2 addition to pt/al2...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology     Volume:  54     ISSN:  0955-3002     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-13     Completed Date:  1988-10-13     Revised Date:  2001-11-13    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  417-27     Citation Subset:  IM; S    
Radiation Center of Osaka Prefecture, Sakai, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Free Radicals
Gamma Rays
Pulse Radiolysis
Structure-Activity Relationship
Reg. No./Substance:
0/Free Radicals; 0/Sulfates; 58-96-8/Uridine; 66-22-8/Uracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Radiation chemistry of d(TpApCpG) in oxygenated solution.
Next Document:  Repair kinetics in mouse lung after multiple X-ray fractions per day.