| Radical scavenging action of flunarizine in rat brain in vitro. | |
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MedLine Citation:
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PMID: 6525007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In view of recent investigations suggesting that generation of free radicals with subsequent peroxidative disintegration of cellular membranes may be involved in ischemic brain damage, free radical scavenging or antioxidant activity of flunarizine, a calcium-entry blocker with brain protective effects, was investigated in vitro. The experimental systems used were 1) prevention of autoxidation in rat brain homogenate, 2) prevention of lipid peroxidation and swelling induced by Fe2+ and ascorbic acid in rat brain mitochondria, and 3) radical scavenging action against diphenyl-p-picrylhydrazyl, a stable free radical. Although flunarizine was shown to be active in any system, the most pronounced activity of this compound was elicited in the mitochondria, where it was three times greater than that of alpha-tocopherol, a typical intracellular antioxidant. This suggests that the free radical scavenging or antioxidant activity of flunarizine may play a role in its brain protective action. |
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Authors:
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K Kubo; I Yoshitake; Y Kumada; K Shuto; N Nakamizo |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 272 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-03-14 Completed Date: 1985-03-14 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 283-95 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants Ascorbic Acid / pharmacology Brain / metabolism* Cinnarizine / analogs & derivatives, pharmacology* Flunarizine Free Radicals Iron / pharmacology Kinetics Lipid Peroxides / metabolism Male Malondialdehyde / metabolism Mitochondrial Swelling / drug effects Oxygen Consumption / drug effects Piperazines / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radicals; 0/Lipid Peroxides; 0/Piperazines; 298-57-7/Cinnarizine; 50-81-7/Ascorbic Acid; 52468-60-7/Flunarizine; 542-78-9/Malondialdehyde; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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