Document Detail


Radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph, and soft-tissue dissection in pancreatic head cancer.
MedLine Citation:
PMID:  18706233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent studies have revealed that the reason for the low surgical resection rate of pancreatic carcinoma partly lies in its biological behavior, which is characterized by neural infiltration. This study aimed to investigate the clinical significance of radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph, and soft-tissue dissection for carcinoma of the pancreatic head. METHODS: Forty-six patients with pancreatic head cancer were treated in our hospital from 1995 to 2005. The patients were divided into two groups: radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph and soft-tissue dissection (group A, n = 25) and routine Whipple's operation (group B, n = 21). There were no significant differences between the two groups in relation to age, gender and preoperative risk factors, and perioperative conditions, pathological data and survival rates were studied. RESULTS: There were no significant differences in tumor size, surgical procedure time, postoperative complications, and time of hospitalization. However, the number and positive rate of resected lymph nodes in group A were significantly higher than those in group B (P < 0.05). The 1- and 3-year survival rate in group A were 80% and 53%, respectively, which was higher than those in group B (P < 0.05). There were significant differences in the survival rates between patients with and without nerve infiltration in group A (P < 0.05). CONCLUSIONS: Radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph and soft-tissue dissection, can effectively remove the lymph and nerve tissues that were infiltrated by tumor. Meanwhile, this method can reduce the local recurrence rate so as to improve the long-term survival of patients.
Authors:
Qin-shu Shao; Zai-yuan Ye; Shu-guang Li; Kan Chen
Related Documents :
15713583 - Primary pancreatic lymphoma. report of five cases.
9308613 - Long-term survival in pancreatic cancer: pylorus-preserving versus whipple pancreatoduo...
2044783 - Hepatic artery ligation with and without portal infusion of 5-fu. a randomized study in...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  121     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1130-3     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310000, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cause of Death
Humans
Lymph Node Excision
Pancreatic Neoplasms / pathology,  surgery*
Pancreaticoduodenectomy / adverse effects,  methods*,  mortality
Retroperitoneal Space / innervation,  pathology,  surgery
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transradial approach for coronary angioplasty in Chinese elderly patients.
Next Document:  Transplantation of autologous bone marrow mononuclear cells for patients with lower limb ischemia.